中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (9): 652-655.doi: 10.3760/cma.j.issn.0412-4030.2019.09.014

• 综述 • 上一篇    下一篇

慢性自发性荨麻疹:奥马珠单抗治疗作用机制与疗效评估

陈玉迪    耿鹏    赵嘉惠    涂平    赵作涛   

  1. 北京大学第一医院皮肤性病科  100034 
  • 收稿日期:2018-06-12 修回日期:2018-08-02 出版日期:2019-09-15 发布日期:2019-08-30
  • 通讯作者: 赵作涛 E-mail:zhaozuotaotao@163.com
  • 基金资助:
    国家自然科学基金中德合作项目(GZ901)

Chronic spontaneous urticaria: therapeutic mechanism of omalizumab and assessment of its clinical efficacy

Chen Yudi, Geng Peng, Zhao Jiahui, Tu Ping, Zhao Zuotao   

  1. Department of Dermatology and Venereology, Peking University First Hospital, Beijing 100034, China

  • Received:2018-06-12 Revised:2018-08-02 Online:2019-09-15 Published:2019-08-30
  • Contact: Zhao Zuotao E-mail:zhaozuotaotao@163.com
  • Supported by:
    Sino-German Cooperation Project of National Natural Science Foundation of China(GZ901)

摘要: 【摘要】 慢性自发性荨麻疹皮疹反复发作,常伴剧烈瘙痒,严重影响患者生活质量。慢性荨麻疹欧洲指南推荐抗IgE单克隆抗体(奥马珠单抗)作为唯一三线治疗方案用于加倍剂量抗组胺药仍不能控制病情的慢性自发性荨麻疹患者。尽管目前大量研究已证实奥马珠单抗治疗慢性自发性荨麻疹的安全性和有效性,但尚未完全阐明其作用机制。本文综述奥马珠单抗在慢性自发性荨麻疹治疗中的作用机制,并对治疗中的疗效预测与监测指标进行探讨。

关键词: 荨麻疹, 免疫球蛋白ε链, 免疫球蛋白E, 奥马珠单抗, 慢性自发性荨麻疹

Abstract: 【Abstract】 Chronic spontaneous urticaria (CSU) is characterized by recurrent wheals with severe itching, and greatly affects the life quality of patients. The European guideline on chronic urticaria recommends the anti-IgE monoclonal antibody omalizumab as the only third-line therapy for patients with CSU whose condition can not be controlled by high doses of antihistamines. Although a lot of researches have shown that omalizumab is effective and safe for the treatment of CSU, its therapeutic mechanisms have not yet been fully elucidated. This review summarizes therapeutic mechanisms of omalizumab in the treatment of CSU, and indices for predicting and monitoring its clinical efficacy.

Key words: Urticaria, Immunoglobulin epsilon-chains, Immunoglobulin E, Omalizumab, Chronic spontaneous urticaria