关键词: 荨麻疹, 诱导性荨麻疹, 激发试验

Abstract: Lu Rongbiao, Su Xiangyang, Yao Tingting, Li Meirong, Li Huizhu, Ye Cuifen, Lai Wei Department of Dermatology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China （Lu RB, Su XY, Li RM, Li HZ, Ye CF, Lai W）; Department of Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China （Yao TT） Corresponding author: Su Xiangyang, Email: sh3355@vip.163.com 【Abstract】 Objective To analyze the rate and distribution of positive provocative tests in patients with inducible urticaria, and to investigate the role of provocative tests in the etiological diagnosis of chronic urticaria. Methods Among patients who visited the special clinic for urticaria in the Department of Dermatology of the Third Affiliated Hospital, Sun Yat-sen University from January 2016 to December 2017, 127 patients with suspected inducible urticaria were selected, and underwent 6 provocative tests for inducible urticaria, including delayed pressure urticaria provocative test （DPUPT）, symptomatic dermographism provocative test （SDPT）, vibratory angioedema provocative test （VAEPT）, cold urticaria provocative test （CUPT）, heat urticaria provocative test （HUPT）, and aquagenic urticaria provocative test （AUPT）. Statistical analysis was carried out by chi-square test for comparison of positive rates between male and female patients. Results Among the 127 patients with suspected inducible urticaria, 106（83.46%） showed one or more positive provocative tests. The positive rate of SDPT was the highest （79.53%, 101/127）, followed by HUPT （22.05%, 28/127） and CUPT （9.45%, 12/127）. The positive rate of HUPT was significantly higher in female patients （30.14%, 22/73） than in male patients（11.11%, 6/54; χ2 = 4.301, P < 0.05）. The patients with positive DPUPT, VAEPT and AUPT all showed positive SDPT responses. Among the 12 patients with positive CUPT reactions, 11 showed positive SDPT responses. Among the 28 patients with positive HUPT reactions, 26 showed positive SDPT responses. Of the 48 patients with one or more positive non-SDPT provocative tests, the patients with 2 positive non-SDPT provocative tests accounted for 18.75%（9/48）. Conclusion Provocation tests for inducible urticaria are of great clinical significance for the etiological diagnosis of chronic urticaria.

Key words: Urticaria, Inducible urticaria, Provocative tests