中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (6): 345-347.

• 论著 • 上一篇    下一篇

皖籍汉人斑秃的遗传流行病学研究

杨杰, 杨森, 刘江波, 王红艳, 孙良丹, 梁燕华, 张学军   

  1. 安徽医科大学皮肤病研究所、安徽医科大学第一附属医院皮肤科 合肥 230022
  • 收稿日期:2004-05-15 出版日期:2005-06-15 发布日期:2005-06-15
  • 通讯作者: 张学军,E-mail:ayzxj@mail.hf.ah.cn E-mail:ayzxj@mail.hf.ah.cn
  • 基金资助:
    国家863基金资助项目(2001AA227031)

Genetic Epidemiology of Alopecia Areata in Chinese Hans

YANG Jie, YANG Sen, LIU Jiang-bo, WANG Hong-yan, SUN Liang-dan, LIANG Yan-hua, ZHANG Xue-jun   

  1. Department of Dermatology and Venereology, First Affiliated Hospital of Anhui Medical University, Institute of Dermatology, Anhui Medical University, Hefei 230022, China
  • Received:2004-05-15 Online:2005-06-15 Published:2005-06-15

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摘要： 目的 描述斑秃患者的遗传流行病学特征和探索可能的遗传模型。方法 应用病例对照研究的方法对1032例斑秃先证者进行遗传流行病学研究。采用Falconer方法和SAGE-REGTL软件进行遗传度和复合分离分析。结果 患者平均发病年龄为28.98±13.43岁,男女之间无差异,82.6%的患者第一次脱发发生在40岁以前。有阳性家族史的有87人(8.43%)。早发组患者比晚发组病情更重、病程更长。先证者一、二、三级亲属的患病率分别为1.58%,0.19%和0.03%,显著高于对照组(P<0.001)。斑秃一、二、三级亲属的遗传度分别为47.16%±2.79%,42.53%±7.36%和22.29%±21.63%,三者加权平均遗传度为46.23%±0.07%。根据SAGE-REGTL结果,斑秃的最佳模型是多基因累加模式。结论 斑秃具有多基因遗传病的特点,在其发病过程中,遗传起了重要的作用。

关键词: 斑秃, 遗传流行病学

Abstract: Objective To describe the genetic epidemiologic features of alopecia areata (AA) patients in China and to presume the possible genetic model of AA. Methods A case-controlled study of 1032 AA patients was performed to analyze the effect of genetic factors on the liability to AA.Complex segregation and heritability analysis were performed using Falconer's method and SAGE-REGTL programs. Results The meanage of onset was 28.98±13.43 years.The difference in the meanage of onset was not significant between males and females.A total of 82.6 percent of patients experienced their first episode of AA before the fourth decades of life.A positive family history of AA was obtained in 8 7 patients (8.43%).The prevalences of AA were 1.58%,0.19% and 0.03% in the first-,second-and third-degree relatives of the probands respectively,which were significantly higher than those in the controls(P<0.001=.The heritabili ties of AA were 47.16%±2.79%,42.53%±7.36% and 22.29%±21.63% in the first-,second-and third-degree relatives,respectively,the weighted mean heritability was 46.23%±0.07%.Based on the REGTL results,the best model was a polyge nicadditive model for AA. Conclusion It can be concluded that AA is a polygenic disease.Genetic factors play an important role in the pathogenesis of AA.

Key words: Alopecia areata, Genetic epidemiology