中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (10): 631-633.

• 论著 • 上一篇    下一篇

皮肤鳞状细胞癌和基底细胞癌中细胞凋亡及C-fos、BNIP1表达

史建强, 陈嵘祎, 樊翌明, 吴志华   

  1. 广东医学院附属医院皮肤科 524001
  • 收稿日期:2005-03-28 发布日期:2005-10-15
  • 通讯作者: 樊翌明,E-mail:ymfan1963@sohu.com E-mail:ymfan1963@sohu.com
  • 基金资助:
    湛江市科技攻关项目(湛科[2003]69-7)

Cell Apoptosis and mRNA Expression of c-fos and BNIPl in Cutaneous Squamous and Basal Cell Carcinomas

SHI Jian-qiang, CHEN Rong-yi, FAN Yi-ming, WU Zhi-hua   

  1. Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China
  • Received:2005-03-28 Published:2005-10-15

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摘要： 目的 观察皮肤鳞状细胞癌(鳞癌)和基底细胞癌(基癌)中细胞凋亡及其与c-fos、BNIP1表达的关系。方法 应用原位末端标记和原位杂交技术检测48例皮肤鳞癌和41例基癌标本中细胞凋亡及C-fos、BNIP1 mRNA表达。结果 鳞癌中凋亡指数(AI)、c-fos mRNA表达明显高于基癌(P<0.01),但BNIP1 mRNA表达在二者间的差异无显著性(P>0.05)。AI在高分化鳞癌中明显增多(P<0.05),但C-fos表达以低分化鳞癌更为明显(P<0.05)。鳞癌中AI与c-fos、BNIP1表达呈显著正相关(P<0.05)。结论 鱗癌中细胞凋亡增多与c-fos表达上调相关,BNIP1在鳞癌和基癌中可能起促凋亡作用。

关键词: 癌, 鳞状细胞, 癌, 基底细胞, 细胞凋亡, 原癌基因蛋白质c-fos, BNIP1

Abstract: Objective To study the relationship between cell apoptosis and mRNA expression of c-fos and BNIPl in cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Methods Cell apoptosis and mRNA expression of c-fos and BNIP1 in 48 SCCs and 41 BCCs were determined by TUNEL and in situ hybridization, respectively. Results Apoptosis index (AI) and c-fos mRNA expression in SCCs were higher than those in BCCs (P<0.01), but BNIPl mRNA expression did not differ between them (P>0.05). AI was significantly higher in well-differentiated SCCs than in poorly differentiated SCCs (P<0.05), which was contrary to the expression of c-fos. Significant positive correlation was found between AI and expression of c-fos and BNIPl (P<0.05) in SCCs. Conclusions The increase of AI in SCCs is related to cfos overexpression. BNIPl is likely to induce the apoptosis in SCC and BCC.

Key words: Carcinoma, squamous cell, Carcinoma, basal cell, Apoptosis, Proto-oncogene proteins cfos, BNIPl