HLA-DQA1及DQB1等位基因与寻常型银屑病遗传易感性研究

中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (2): 120-123.

HLA-DQA1及DQB1等位基因与寻常型银屑病遗传易感性研究

张学军, 魏生才, 王再兴, 张安平, 杨森

安徽医科大学第一附属医院皮肤科合肥 230032

收稿日期:2001-06-20 出版日期:2002-04-15 发布日期:2002-04-15
基金资助:
安徽省自然科学基金资助(99044237)

The Association of HLA-DQA1 and DQB1 Alleles with Genetic Susceptibility to Psoriasis Vulgaris in Han Chinese

ZHANG Xuejun,WEI Shengcai,WANG Zaixing,ZHANG Anping, YANG Sen

Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

Received:2001-06-20 Online:2002-04-15 Published:2002-04-15

摘要/Abstract

摘要： 目的探讨HLA-DQA1和DQB1等位基因与汉族人寻常型银屑病遗传易感性。方法利用聚合酶链反应-序列特异引物(PCR-SSP)法,对189例银屑病患者和273例健康人的HLA-DQA1和DQB1等位基因进行检测。结果 ①HLA-DQA1*0104和DQA1*0201与汉族人银屑病呈正相关性(Pc<0.05);DQA1*0501与汉族人银屑病呈负相关(Pc<0.001).②HLA-DQA1*0104、DQA1*0201和DQA1*0501等位基因与Ⅰ型银屑病发病有关。③HLA-DQA1*0104和DQA1*0201等位基因在有家族史和无家族史患者中的频率显着性增高。HLA-DQA1*0501仅在无家族史银屑病患者中显着性下降。结论 ①HLA-DQA1*0104和DQA1*0201可能是银屑病的易感基因或与易感基因相连锁;DQA1*0501等位基因可能具有阻止汉族人发生银屑病的作用。②有家族史和无家族史银屑病患者在其遗传背景上可能存在差异。

关键词: 银屑病, HLA-DQ抗原, 等位基因

Abstract: Objective To explore HLA-DQA1 and DQB1 alleles in their association with genetic susceptibility to psoriasis vulgaris(PV) in Han Chinese. Method Polymerase chain reaction sequence specific primers (PCR-SSP) method was used to analyze the frequencies of HLA-DQA1 and DQB1 alleles among 189 patients with PV and 273 healthy controls. Results ①HLA-DQA1*0104 and DQA1*0201 alleles were positively associated with PV (Pc<0.05); HLA-DQA1*0501 allele was negatively associated with PV(Pc<0.001). ②HLA-DQA1*0104, DQA1*0201 and DAQ1*0501 alleles were associated with typeⅠpsoriasis only. ③HLA-DQA1*0104 and DQA1*0201 alleles were increased in patients with or without family history. DQA1*0501 allele was only decreased in patients without family history. Conclusions ①HLA-DQA1*0104 and DQA1*0201 alleles may be the susceptible genes or have close linkage with susceptible genes. HLA-DQA1*0501 allele may have protective effects on development of PV in the Chinese. ②There may be a difference in genetic background between psoriasis patients with and without family history.

Key words: Alleles, Psoriasis, HLA-DQ antigens

张学军, 魏生才, 王再兴, 张安平, 杨森. HLA-DQA1及DQB1等位基因与寻常型银屑病遗传易感性研究[J]. 中华皮肤科杂志, 2002, 35(2): 120-123.

ZHANG Xuejun,WEI Shengcai,WANG Zaixing,ZHANG Anping, YANG Sen. The Association of HLA-DQA1 and DQB1 Alleles with Genetic Susceptibility to Psoriasis Vulgaris in Han Chinese[J]. Chinese Journal of Dermatology, 2002, 35(2): 120-123.

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