中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (2): 111-113.

• 论著 • 上一篇    下一篇

寻常型银屑病患者血管内皮生长因子及单核细胞趋化因子-1表达的研究

陈积愫, 郑敏   

  1. 浙江大学医学院附属第二医院皮肤科 杭州 310009
  • 收稿日期:2001-01-15 出版日期:2002-04-15 发布日期:2002-04-15
  • 基金资助:
    浙江省自然科学基金(399126);浙江大学医学院附属第二医院学科发展基金(R-2108)

Expression of Vascular Endothelial Growth Factor and Monocyte Chemoattractant Protein-1 in Patients with Psoriasis

CHEN Jisu, ZHENG Min   

  1. Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
  • Received:2001-01-15 Online:2002-04-15 Published:2002-04-15

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摘要： 目的 探讨血管内皮生长因子(VEGF)、单核细胞趋化因子-1(MCP-1)在银屑病患者皮肤中的表达及其意义。方法 用免疫组化法检测银屑病患者皮损、非皮损及正常人皮肤中VEGF、MCP-1的表达与分布。用双抗体夹心酶联免疫吸附法检测患者血清中VEGF、MCP-1水平。结果 ①银屑病患者皮损及非皮损中VEGF表达较正常人皮肤明显增强(P<0.05).皮损中MCP-1表达较非皮损及正常人皮肤明显增强(P<0.05).②患者血清中VEGF水平明显高于正常人(P<0.05),MCP-1水平与正常人比较差异无显着性(P>0.05).③皮损角质形成细胞中VEGF、MCP-1的表达与PASI评分无显着相关性(P>0.05)。结论 VEGF、MCP-1的表达增强在银屑病的发病机制中可能起重要作用。

关键词: 银屑病, 内皮生长因子, 趋化细胞因子类,CC

Abstract: Objective To study the production and distribution of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein 1 (MCP-1) in the skin and sera of patients with psoriasis and their roles in the pathogenesis of psoriasis. Methods Levels of VEGF and MCP-1 in sera were measured using double antibody sandwich enzyme linked immunosorbent assay(ELISA) in patients with psoriasis. The expression and distribution of VEGF and MCP-1 in psoriatic lesions, non-lesional skin and normal controls were detected by immunohistochemical method. Results ①The expression of VEGF in lesional skin and non-lesional skin of psoriasis patients was higher than that in normal controls. Levels of MCP-1 were increased in lesional skin than those in non-lesional skin and normal controls.②Serum levels of VEGF were significantly increased in psoriasis as compared with normal control. There was no significant difference in serum levels of MCP-1 between patients and controls.③There was no correlation between the expression of MCP-1 or VEGF of psoriatic lesion and PASI index. Conclusion Overexpression of two cytokines, VEGF and MCP-1, known to promote new blood vessel formation may contribute to the pathogenesis of psoriasis.

Key words: Psoriasis, Endothelial growth factors, Chemokines,CC