中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (2): 113-115.

• 论著 • 上一篇    下一篇

黄芪注射液治疗银屑病患者的临床观察和实验研究

刘晓明1, 齐欣2, 宋智琦1, 崔春华1, 林熙然1   

  1. 1. 大连医科大学附属第一医院皮肤科 116011;
    2. 鞍山钢铁集团公司铁西医院皮肤科
  • 收稿日期:2000-03-28 出版日期:2001-04-15 发布日期:2001-04-15

Clinical and Experimental Observation on Treatment of Psoriasis with Radix Astragali Injectio

LIU Xiaoming1, QI Xin2, SONG Zhiqi1   

  1. Department of Dermatology, First Affili ated Hospital of Dalian Medical University 116011, China
  • Received:2000-03-28 Online:2001-04-15 Published:2001-04-15

摘要: 目的 观察黄芪注射液治疗银屑病的临床疗效并对其可能的作用进行实验研究。方法 各31例寻常型银屑病分别用综合治疗和在此基础上加用黄芪注射液,对比观察临床疗效。同时研究黄芪煎剂和黄芪注射液对小鼠阴道上皮细胞增殖、增殖细胞核抗原表达、鼠尾鳞片表皮分化和血浆内皮素-1水平的影响。结果 加用黄芪注射液与单纯综合治疗相比皮疹消退时间明显提前,治愈率明显提高。动物实验表明黄芪注射液对上述4个指标均有作用。其作用均比黄芪煎剂强。结论 黄芪注射液治疗银屑病有效,其作用可能是阻断多个发病环节。

关键词: 银屑病, 黄芪

Abstract: Objective To observe the therapeutic effect of Radix Astragali Injectio on psoriasis and its possible pharmaceutical mechanism. Methods Two groups of patients with psoriasis vulgaris were treated with either comprehensive regi men or comprehensive regimen plus Radix Astragali Injectio. The clinical respons es in both groups were compared. Meanwhile, the effects of Radix Astragali Decoction and Injectio on proliferation of vaginal epithelium, PCNA expression, differentiation of tail scale epidermis and plasma ET-1 were assessed in mouse model. Results It was shown that psoriatic lesions began to fade significantly earlier in Radix Astragali group than in routine comprehensive treatment group. The clinical cure rate was significantly higher in Radix Astragali group also. Animal experiment indicated that Radix Astragali Injectio had effects on all 4 indices mentioned above and the effects of the Injectio was stronger than that of the D ecoction. Conclusions Radix Astragali Injectio is effective for psoriasis vulgaris. Its therapeutic effects may be explained by blocking multiple pathogenetic linkage.

Key words: Psoriasis, Astragalus membranaceus