中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (2): 101-102.

• 论著 • 上一篇    下一篇

银屑病患者血清中细胞因子状态的研究

张良芬, 吴勤学, 王群   

  1. 中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042
  • 收稿日期:2000-09-08 出版日期:2001-04-15 发布日期:2001-04-15
  • 基金资助:
    国家高校博士点基金资助(199711)

Study on the Levels of Cytokines in Sera of Patients with Various Types of Psoriasis

ZHANG Liangfen, WU Qinxue, WANG Qun   

  1. Institute of Dermatology, Chinese Acad emy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2000-09-08 Online:2001-04-15 Published:2001-04-15

摘要: 目的 探讨各型银屑病患者血清中细胞因子状态。方法 采用双抗体夹心酶联免疫吸附试验检测15例点滴状银屑病、23例斑块状银屑病、9例脓疱型银屑病、9例关节病型银屑病和9例红皮病型银屑病患者血清中6种细胞因子的水平。结果 点滴状银屑病组可溶性白介素2受体(sIL-2R)显著高于对照组(P<0.01);斑块状银屑病组白介素(IL)-4、-12和sIL-2R显著高于对照组(P<0.05或<0.01);脓疱型银屑病组IL-4和IL-10显著高于正常对照组(P<0.05);关节病型银屑病组IL-10显著高于对照组(P<0.01);红皮病型银屑病组中6种细胞因子水平均高于正常对照组,但差异无显著性。各型银屑病组IL-4均值与干扰素γ均值比值脓疱型组为1.57,斑块状组为0.61,点滴状组为0.30,红皮病型组为0.24,关节病型组为0.02。结论 各型银屑病患者血清中细胞因子的状态不同。

关键词: 银屑病, 白细胞介素类, 干扰素Ⅱ型, 受体,白细胞介素

Abstract: Objective To investigate the levels of cytokines in sera of patien ts with various types of psoriasis. Methods Six cytokines, sIL-2R、 IL-2、-4、-10、-12 and IFN-γ, were detected by sandwich ELISA in the sera from 15 patients with guttate psoriasis, 23 plaque psoriasis, 9 pustular psoriasis, 9 arthropathic psoriasis and 9 erythrodermic psoriasis. Results Significantly hig her levels of cytokines were observed in guttate psoriasis for sIL-2R (P<0.01), in plaque psoriasis for IL-4,-12 and sIL-2R (P<0.05 or <0.01), in pus tular psoriasis for IL-4 and-10 (P<0.05), in arthropathic psoriasis for IL-10 (P< 0.01), in comparison with the controls. The levels of the six cytokine s were increased in erythrodermic psoriasis with no significant difference from the controls. The ratio of the average level of IL-4 to IFN-γ was 1.57 in pu stular psoriasis, 0.61 in plaque psoriasis, 0.30 in gutatte psoriasis, 0.24 in e rythrodermic psoriasis, and 0.02 in arthropathic psoriasis. Conclusion There is different expression of cytokines in sera of patients with various types of psoriasis.

Key words: Interferon typeⅡ, Receptor,interleukin, Psoriasis, Interleukins