皮肤NK/T细胞淋巴瘤的临床病理及其与EB病毒关系的研究

摘要/Abstract

摘要： 目的探讨皮肤NK/T细胞淋巴瘤的临床病理特点、免疫表型及与EB病毒感染的关系。方法应用免疫组织化学染色,选用CD45RO、CD3ε、TIA-1、CD20、Ki-B5、CD68和LMP1等抗体;用EBER1/2原位杂交检测EB病毒编码的小分子RNA。结果 5例皮肤NK/T细胞淋巴瘤患者占同期皮肤恶性淋巴瘤的5.68%;男4例,女1例,平均年龄34岁,主要表现为皮肤无症状肿块,2例有溃疡形成;组织学特征为肿瘤在真皮和皮下脂肪内,易形成血管浸润性和破坏性病变,瘤细胞大小、形态各异;瘤细胞表达T细胞标记(5/5)和NK细胞或细胞毒性T细胞标记TIA-1(4/4),EBER1/2(3/4)。结论皮肤NK/T细胞淋巴瘤具有临床病理独特性,与EB病毒感染有较强的相关性。

关键词: 皮肤肿瘤, 淋巴瘤, NK/T细胞, 疱疹病毒4型, 人

Abstract: Objective To study the clinicopathologic features and immunophenotype of cutaneous NK/T cell lymphoma and the association with Esptein-Barr virus (EBV) infection. Methods Five cases of cutaneous NK/T cell lymphoma were studied. Histologic sections of embedded tissues were immunohistochemically stained with CD45RO, CD3ε, TIA-1, CD20, Ki-B5, CD68 and LMP1 antibodies, and in situ hybridization for EBV-encoded small nuclear RNAs-EBER1/2 was also carried out. Results Cutaneous NK/T cell lymphoma accounted for 5.68% in the cutaneous malignant lymphoma in the same period of observation. There were 4 male and 1 female patients, and the mean age was 34 years. The main clinical manifestations were asymptomatic nodules and masses, which were accompanied by ulcers in 2 cases. Histologically, the tumors were mainly located in the dermis and subcutaneous adipose tissue, the infiltrated lymphoid cells were pleomorphic, and angiocentricity and angiodestruction were found in almost all cases. Immunohistochemical stain showed that five cases were T cell phenotype and the expression rate of TIA-1 was 100% (4/4). The EBV was present in three of four cases by in situ hybridization. Conclusions Cutaneous NK/T cell lymphoma presents with unique and diagnostic clinicopathologic features, and is strongly associated with EBV.

Key words: Skin neoplasms, Lymphoma, NK/T-cell, Herpesvirus 4, human

王琳, 刘卫平, 李甘地, 李俸媛, 李金范, 周光平. 皮肤NK/T细胞淋巴瘤的临床病理及其与EB病毒关系的研究[J]. 中华皮肤科杂志, 2000, 33(6): 395-397.doi:

WANG Lin, LIU Weiping, LI Gandi. Investigation of the Clinicopathologic Features of Cutaneous NK/T Cell Lymphoma and Epstein-Barr Virus Infection[J]. Chinese Journal of Dermatology, 2000, 33(6): 395-397.doi:

参考文献

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