初级纤毛在常见皮肤肿瘤中的研究进展

doi:10.3760/cma.j.issn.0412-4030.2019.05.017

摘要/Abstract

摘要： 【摘要】近年来，生物医学领域的一个新的研究方向就是初级纤毛。初级纤毛常常在不同细胞的表面被发现，其体型相对微小，并且具体结构尚不清楚。初级纤毛在细胞的感官方面起着重要作用，细胞可通过初级纤毛来感知外界各种信号的变化，包括机械和化学信号，并且初级纤毛可协助细胞将其转导至细胞内部从而产生相应的细胞应答。近年的研究发现，在胚胎发育和细胞恶变的过程当中，初级纤毛也扮演着重要角色。对该过程的深入研究，会深化人们对细胞恶变以及肿瘤演进过程的理解和认识。本文通过查阅相关文献，综述了初级纤毛与常见皮肤肿瘤之间的关系及潜在的靶点，以期为将来的研究提供参考及新思路。

关键词: 纤毛, 皮肤肿瘤, 初级纤毛, 结构, 功能

Abstract: 【Abstract】 Primary cilium has attracted increasing attention in the biomedical field in recent years. It exists in the surface of various cells and is micro?sized, but its complex structures have not been clear. The primary cilium has an important role in sensory perception. Cells can receive extracellular mechanical and chemical signals through primary cilia, and primary cilia can assist in transferring signals into cells, followed by cellular responses. Recent studies have shown that the primary cilium also plays an important role in embryonic development and malignant transformation of cells. The investigation into primary cilia will facilitate the understanding of malignant transformation of cells and development of tumors. According to the related literature in recent years, this review summarizes the relationship between the primary cilium and common skin tumors, as well as potential targets for these tumors, so as to provide references and new sights for further researches.

Key words: Cilia, Skin neoplasms, Primary cilia, Structure, Function

杨京润郑力强黄敏巴伟李承新. 初级纤毛在常见皮肤肿瘤中的研究进展[J]. 中华皮肤科杂志, 2019, 52(5): 353-356.

Yang Jingrun, Zheng Liqiang, Huang Min, Ba Wei, Li Chengxin. Role of primary cilia in common skin tumors[J]. Chinese Journal of Dermatology, 2019, 52(5): 353-356.

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