中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (1): 71-74.doi: 10.35541/cjd.20180696

• 综述 • 上一篇    

组蛋白甲基转移酶EZH2参与淋巴瘤发病机制的研究进展

甘璐    陈浩    孙建方   

  1. 中国医学科学院  北京协和医学院  皮肤病医院病理科,南京  210042
  • 收稿日期:2018-08-17 修回日期:2019-03-08 发布日期:2019-12-31
  • 通讯作者: 陈浩;孙建方 E-mail:CH76CH@163.com; fangmin5758@aliyun.com
  • 基金资助:
    中国医学科学院医学与健康科技创新工程项目(CIFMS-2017-I2M-1-017);北京协和医学院协和青年科研基金(3332017168)

Histone methyltransferase EZH2 in the pathogenesis of lymphoma

Gan Lu, Chen Hao, Sun Jianfang#br#   

  1. Department of Pathology, Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2018-08-17 Revised:2019-03-08 Published:2019-12-31
  • Contact: Chen Hao; Sun Jianfang E-mail:CH76CH@163.com; fangmin5758@aliyun.com
  • Supported by:
    CAMS Innovation Fund for Medical Sciences (CIFMS-2017-I2M-1-017); PUMC Youth Fund (3332017168)

摘要: 【摘要】 表观遗传学修饰是癌症发生发展的重要原因之一。果蝇zeste基因增强子的人类同源物2 (EZH2)是表观遗传抑制因子PcG家族的重要成员之一,可对组蛋白H3第27位赖氨酸进行三甲基化,从而参与调控细胞周期、细胞衰老和细胞分化等。近年来,在多种实体瘤及B细胞淋巴瘤中检测到EZH2过表达或突变,但EZH2在部分T细胞淋巴瘤中的表达情况和作用机制尚不明确,且其在不同肿瘤发生中的作用机制不完全一致,有待进一步深入研究。

关键词: 甲基转移酶类; 淋巴瘤, B细胞; 淋巴瘤, T细胞; 果蝇zeste基因增强子的人类同源物2

Abstract: 【Abstract】 Epigenetic modification is one of the important causes for the occurrence and development of cancers. Enhancer of zeste homolog 2 (EZH2), as an important member of the epigenetic suppressor polycomb group (PcG), can tri-methylate lysine at amino acid position 27 of histone H3 gene, and participates in the regulation of cell cycle, cell aging and cell differentiation. Recently, overexpression or mutation of EZH2 has been detected in a variety of solid tumors and B-cell lymphomas. However, the expression status and action mechanism of EZH2 in some T-cell lymphomas are still unclear, and its action mechanisms in different tumors are not completely consistent, which need further study.

Key words: Methyltransferases, Lymphoma, B-cell, Lymphoma, T-cell, Enhancer of zeste homolog 2

引用本文

甘璐 陈浩 孙建方. 组蛋白甲基转移酶EZH2参与淋巴瘤发病机制的研究进展[J]. 中华皮肤科杂志, 2020,53(1):71-74. doi:10.35541/cjd.20180696

Gan Lu, Chen Hao, Sun Jianfang. Histone methyltransferase EZH2 in the pathogenesis of lymphoma[J]. Chinese Journal of Dermatology, 2020, 53(1): 71-74.doi:10.35541/cjd.20180696