中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (2): 90-92.

• 论著 • 上一篇    下一篇

链球菌、分支杆菌及皮肤鳞屑蛋白与银屑病关系的研究

侯伟, 吴勤学, 陈小红, 蔡秀玲, 张良芬, 尹跃平, 邵长庚   

  1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京 210042
  • 收稿日期:1999-06-07 发布日期:2000-04-15

Study on the Relationship Between Psoriasis and Streptococcus, Mycobacterium and Scale Proteins

HOU Wei, WU Qinxue, CHEN Xiaohong   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042
  • Received:1999-06-07 Published:2000-04-15

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摘要： 目的 探讨β-溶血性链球菌、分支杆菌及皮肤鳞屑蛋白与银屑病的关系。方法 用常规方法培养分离银屑病患者咽拭物。用ELISA测定银屑病患者血中抗β-溶血性链球菌超声抗原、结核分支杆菌粗脂抗原及银屑病鳞屑蛋白的相应抗体水平。结果 ①寻常型银屑病患者咽部菌群以β-溶血性链球菌为主。②各型银屑病患者血中抗β-溶血性链球菌抗体均有不同程度的升高,其中点滴状银屑病患者以IgG为主,斑块状患者以IgM为主,与正常人对照比较差异均有显著性。③各型银屑病患者血中均未测到抗结核杆菌粗脂抗原的抗体。④关节型银屑病患者组抗皮肤鳞屑蛋白的抗体水平普遍较高,特别是抗原2和抗原14,患者与正常人组之比分别高达2.8和2.0。结论 ①寻常型银屑病患者咽部菌群以β-溶血性链球菌为主。②不同银屑病患者组升高的抗链球菌抗体类型不一,提示在疾病的不同类型和不同阶段,机体对链球菌的反应不同。③结核杆菌粗脂抗原与银屑病的关系不密切。④鳞屑蛋白抗原2和抗原14可能与关节型银屑病有一定关系。除此之外,鳞屑蛋白在其它各型银屑病的发病机制中可能并不重要。

关键词: 银屑病, 链球菌, 无乳, 分支杆菌, 结核

Abstract: Objective To study the relationship between psoriasis and Streptococcus, Mycobacterium,and scale proteins from psoriatic patients(SPPs). Methods The throat swabs of patients with psoriasis vulgaris were cultured. Antibodies against streptococcal antigens,SPPs and crude lipids from M.tuberculosis were detected by ELISA for both psoriatic patients and healthy controls. Results ① Beta-hemolytic streptococci were the most common flora isolated from the throat swabs in the patients with psoriasis vulgaris.② The titres of antibodies against streptococcal antigens increased significantly in all types of psoriasis. The level of IgG antibody was the highest in guttate type of psoriasis while IgM antibody was the highest in plaque type of psoriasis.③ No antibody against crude lipids extracted from M.tuberculosis was detected in all types of psoriasis.④ Patients with psoriasis arthropathica had a significantly higher titre of antibody against SPPs than that in patients with other types of psoriasis and healthy controls. The titres of antibodies against SPPs2 and SPPs14 were 2.8 and 2.0 times higher respectively in the patient group than those in the control group. Conclusions ① The predominant bacterial flora is Streptococcus in the throat swabs from patients with psoriasis vulgaris.② There are different kinds of antibodies against Streptococcus in the patients with different types of psoriasis, which suggests that the immunoreaction to the Streptococcus varies with different types and stages of psoriasis.③ No antibody against crude lipids from M.tuberculosis is detected in all types of psoriasis.④ SPPs2 and SPPs14 may play a role in the pathogenesis of psoriasis arthropathica.

Key words: Psoriasis, Mycobacterium tuberculosis, Streptococcus agalactiae