中华皮肤科杂志 ›› 1999, Vol. 32 ›› Issue (5): 326-327.

• 论著 • 上一篇    下一篇

中药痤疮冲剂对兔耳实验模型抗角化作用的研究

柴宝, 黄畋   

  1. 大连医科大学第二临床学院皮肤科 辽宁 116023
  • 收稿日期:1998-10-07 修回日期:1999-02-05 出版日期:1999-10-15 发布日期:1999-10-15

Experimental Study on Chinese Traditional Medicine “Powder to be Infused for Acne”in Rabbit Ear

CHAI Bao, HUANG Tian   

  1. Department of Dermatology, Second Affiliated Hospital, Dalian Medical University, Dalian 116023
  • Received:1998-10-07 Revised:1999-02-05 Online:1999-10-15 Published:1999-10-15

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摘要： 目的 建立痤疮实验动物模型,并用来观察中药的抗粉刺作用.方法 采用Kligman法煤焦油外涂于白色家兔耳管开口处,每日1次,连续2周,然后将白色家兔分为两组,第1组灌饲痤疮冲剂2周,第2组不做任何处理.结果 外涂煤焦油2周后,肉眼可见兔耳呈粉刺样发疹,光镜、电镜下观察其改变与人类粉刺相似.又经过 2周后,第1组粉刺样改变明显减轻,第2组未见明显改变.结论 兔耳粉刺实验动物模型具可重复性,并能用于观察药效;中药痤疮冲剂能减少粉刺动物模型的毛囊角栓和减轻真皮炎症.

关键词: 痤疮, 中药, 动物模型

Abstract: Objective To establish an experimental animal model for acne to observe the anticomedone effect of “Powder to be infused for acne".Methods According to Kligman's method,coal tar was applied daily to the area nearby the opening of albino rabbit ear canal for two weeks.Then,the rabbits were divided into two groups,the first group was fed with the Powder,and the second group not.Results Acniform lesions on the rabbit ear could be seen two weeks later,which were similar to the findings of acne in human beings under optic microscope and transmission electron microscope.The changes of first group markedly improved 4 weeks later,but no change in the second group.Conclusion This experimental animal model of acne can be repeated and might be used to observe the effect of drugs,and the “Powder to be infused for acne" could reduce the follicular keratinous plug and the dermal inflammation.

Key words: Acne, Chinese traditional medicine, Animal model