中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (6): 357-359.

• 论著 • 上一篇    下一篇

变应性疾病患者血清IL-4、sCD23的研究

张开明1, 李秉煦2, 唱文娟1, 尹兴平1, 杨小英1, 周敏1   

  1. 1. 太原市中心医院皮肤科 030009;
    2. 温州医学院第一附属医院皮肤科
  • 收稿日期:1997-09-23 修回日期:1998-01-19 出版日期:1998-12-15 发布日期:1998-12-15

Study on Serum Levels of IL-4 and sCD23 in Patients with Allergic Diseases

Zhang Kaiming1, Li Binxu2, Chan Wenjuan1   

  1. Department of Dermatology, Taiyuan Central Hospital, Taiyuan 030009
  • Received:1997-09-23 Revised:1998-01-19 Online:1998-12-15 Published:1998-12-15

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摘要： 目的 为了解几组变应性疾病患者血清IL-4和sCD23水平及IL-4对sCD23(CD23)产生的影响.方法 采用ELISA法对荨麻疹、湿疹及过敏性鼻炎患者血清、外周血单-核细胞(PBMC)及培养条件下IL-4、sCD23(CD23)水平及调控关系进行了研究.结果 ①3组疾病血清_IL-4及sCD23水平均明显高于正常人对照组(P<0.05～0.01), sCD23与IL-4之间具有明显的正相关关系(r=0.68～0.92, P<0.01);②rIL-4可促进PBMC产生和表达sCD23(CD23), 湿疹患者rIL-4对PBMC产生sCD23的诱导能力比正常对照组明显增强.结论 IL-4及sCD23参与了变应性疾病的发展过程, IL-4诱导PBMC产生sCD23为时间效应关系.

关键词: 荨麻疹, 湿疹, 鼻炎, 白细胞介素4, 受体IgE

Abstract: Objective To investigate the serum levels of IL-4 and sCD23 in patients, with allergie diseases and the effect of IL-4 to the produetion of sCD23.Methods The levels of 11-4 and sCD23 in the sera and peripheral blood mononuclear cells(PBMC)from palients with urticaria, eezema and rhand the lever of CD23 in the cultured PBMC with and without exogenous IL-4 were measured by ELISA Results (1) The levels of IL-4 and sCD23 were higher in patients with allergic diseases than those in conlrols, and then were positive correlation between IL-4 and sCD23(r=0.68～0.92. P<0.0l):(2)rIL-d could promote the produetion and expression of sCD23(CD23)in PBMC.this effect was much more remarkable in PBMC from patient, with eczema than that from controls.Conclusion The results contfirm that 11.-4 and sCD23 play a role in the pathogenesis of allergic diseases.

Key words: Urticaria, Eczema, Rhinitis, Interleukin-4, Receptors IgE