中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (6): 354-356.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者血清DNA酶测定的临床意义

曾凡钦, 陈宜芳, 李伯有, 林宝珠, 许德清   

  1. 中山医科大学孙逸仙纪念医院皮肤科, 广州 510120
  • 收稿日期:1998-04-13 修回日期:1998-06-22 出版日期:1998-12-15 发布日期:1998-12-15

The Measurement of Deoxyribonuclease and Its Clinical Significance in Patients with SLE

Zeng Fanqin, Chen Yifang, Li Boyon   

  1. Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sem University of Medical Sciences, Guangzhou 510120
  • Received:1998-04-13 Revised:1998-06-22 Online:1998-12-15 Published:1998-12-15

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摘要： 目的 研究血清DNA酶(DNase)浓度异常在系统性红斑狼疮(SLE)发生发展中所起的作用.方法 于国内首次用单和酶扩散法检测了63例SLE患者 结果 患者血清中DNase浓度明显低于正常人;活动期患者明显低于缓解期患者;SLE伴肾损害患者低于非肾损害患者.血清DNase的浓度下降与DNA含量升高呈负相关;与血沉、ANA呈负相关;与补体C3、C4呈正相关;与病情活动积分呈负相关 结论 SLE患者由于其DNase水增低下, 使得血循环中含DNA的自身抗原长期滞留, 发挥免疫原性, 并与抗DNA抗体结合形成免疫复合物, 造成免疫损伤.患者血清DNase水平低下在SLE的发病机制中起着一定作用.

关键词: 红斑狼疮, 系统性, 脱氧核糖核酸酶类

Abstract: Objective To study the role of abmormal comeetration, of DNase in the development, of SLE.Methods The coneentration of DNase was measured by single radial enzynme diffusion method in the sera of 63 SLE patients.Results The coneentration of DNase in the patients was significantly lower tha in healthy indivduals, signifieantly lower patients at active slage than in remission, and Iowest in patients with lupus nephrilis.The deerease of serum DNase was negatively eorlreIated with the increase of serum DNA. The level of DNase was Hegatively correlated with ANA and ESR.positively correlated with C3.C4.and negalively correlated with the severitv of the disease Conclusion The above data suggest that the decrease of serum DNase make, the persistence of DNA in the blood eireulation which combines with anti DNA antibody to form immune complex resulting in autoimmune lesions.The deereaset of serum DNase an important role in the pathogenesis SLE.

Key words: Lupus erythematosus, systemic, Deoxyribonueleases