中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (6): 377-379.

• 论著 • 上一篇    下一篇

光溶血反应检测氯丙嗪光毒性的实验研究

胡跃, 阎春林, 廖康煌   

  1. 上海医科大学皮肤病研究所 200040
  • 收稿日期:1997-02-04 修回日期:1997-06-16 出版日期:1997-12-15 发布日期:1997-12-15
  • 基金资助:
    卫生部基金

Study on Photohemolysis in Assessment of Chlorpromazine Phototoxicity in vitro

Hu Yue, Yan Chunlin, Liao Kanghuang   

  1. Institute of Dermatology, Shanghai Medical University, Shanghai 200040
  • Received:1997-02-04 Revised:1997-06-16 Online:1997-12-15 Published:1997-12-15

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摘要： 为了避免因服药而引起的皮肤光敏损害,建立了以红细胞为底物,长波紫外线(UVA)为光源,检测光敏药物氯丙嗪光毒性的光溶血反应方法.结果:发现氯丙嗪在UVA的照射下,随着照射剂量和药物浓度的增加,溶血现象也随之变化,而氯丙嗪未经UVA照射则不造成溶血反应.该方法的建立对于预检市场上不断增多的药物中有无光毒性物质,监测和控制药物性光毒性皮肤病的发生提供实验研究依据.

关键词: 氯丙嗪, 紫外线, 光敏感障碍

Abstract: In order to avoid drug induced cutaneous photosensitivity, photohemolysis test was conducted to assess the phototoxicity of chlorpromazine in this study. The result showed that the hemolysis was induced by chlorpromazine after irradiation of UVA. The degree of hemolysis was correlated with the increasing of UVA dosage and chlorpromazine concentration, and chlorpromazine could not induce hemolysis without UVA irradiation. It suggests that this test system can be used to detect and monitor the phototoxic drugs.

Key words: Chlorpromazine, Ultraviolet ray, Photosensitivity disorders