中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (2): 96-92.

• 论著 • 上一篇    下一篇

银屑病患者血浆内皮素含量检测

涂彩霞1, 林熙然1, 郭伟1, 谷玲2   

  1. 1. 大连医科大学附属第一医院皮肤科 116011;
    2. 大连医科大学附属第一医院核医学科
  • 收稿日期:1996-04-01 修回日期:1996-09-01 出版日期:1997-04-15 发布日期:1997-04-15

An Assay of the Levels of Plasma Endothelin in Patients with Psoriasis

Tu Caixia1, Lin Xiran1, Guo Wei1   

  1. The First Affiliated Hospital of Dalian Medical University, Dalian 116011
  • Received:1996-04-01 Revised:1996-09-01 Online:1997-04-15 Published:1997-04-15

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摘要： 为了探讨内皮素与银屑病的关系及其在发病机理中的作用,采用放射免疫分析法检测了32例正常人及54例银屑病患者血浆内皮素的变化,其中寻常型银屑病45例(进行期32例,静止期13例),红皮病型银屑病9例.结果显示:正常人血浆内皮素水平为43.5±15.71pg/ml,银屑病患者血浆内皮素含量为62.01±21.15pg/ml,较正常对照组显着增高(P<0.01),红皮病型又较寻常型患者的血浆内皮素水平为高(P<0.05).寻常型银屑病患者中,进行期与静止期相比其内皮素水平虽有增高,但无显着性差异(P>0.05).本研究提示内皮素可能与银屑病的发病有关,进一步了解其作用机理,可能对银屑病的防治具有重要意义.

关键词: 银屑病, 内皮素

Abstract: In order to study the relationship between endothelin and psoriasis, we determined the plasma levels of endothelin with the method of radioimmunoassay in 54 patients with psoriasis in comparison with 32 normal subjects. Among the cases of psoriasis, 45 were psoriasis vulgaris (32 in progressive stage and 13 in stable stage) while 9 were erythrodermic psoriasis. The results showed that the level of plasma endothelin in normal controls was 43.5±15.71pg/ml, while the value of psoriatics was 62.01±21.15 pg/ml. The latter was significantly higher than the former (P<0.01). The level of plasma endothelin in erythrodermic psoriasis was higher than that of psoriasis vulgaris(P<0.05). In psoriasis vulgaris, the plasma levels of endothelin between progressive stage and stable stage were not significantly different. The above mentioned data suggest that endothelin may have a role in the pathogenesis of psoriasis. It is deemed that further study on the mechanism of action of this substance may be helpful in developing reasonable treatment for psoriasis.

Key words: Psoriasis, Endothelin