中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (2): 88-90.

• 论著 • 上一篇    下一篇

银屑病患者血清中链球菌抗体的研究

江沁, 冯信忠   

  1. 上海第二医科大学附属瑞金医院皮肤科 200025
  • 收稿日期:1996-06-03 修回日期:1996-12-24 出版日期:1997-04-15 发布日期:1997-04-15

The Study of Streptococcal Antigen in Psoriasis

Jiang Qin, Feng Xinzhong   

  1. Department of Dermatology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025
  • Received:1996-06-03 Revised:1996-12-24 Online:1997-04-15 Published:1997-04-15

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摘要： 为了进一步证实链球菌感染与银屑病的关系,我们应用免疫印迹法测试了银屑病患者血清中抗链球菌、抗金黄色葡萄球菌及抗白念珠菌抗体含量.发现点滴型银屑病患者的抗链球菌抗体含量不仅显着高于正常人对照组(P<0.01),亦高于慢性斑块型银屑病患者(P<0.05);但其抗金黄色葡萄球菌、抗白念珠菌抗体含量与对照组相比,结果均无显着性差异(P>0.05).本研究证明了链球菌感染与点滴型银屑病密切相关.

关键词: 银屑病, 链球菌感染, 免疫印迹

Abstract: The immune response to streptococcus in 40 patients with acute guttate psoriasis (AGP) and 10 patients with chronic plaque psoriasis (CPP) has been studied using immunoblotting technique (IBT). The immune responses to staphylococcus and Candida albicans in patients with AGP were also studied using this technique. Patients with AGP had a significantly higher (P<0.01) anti.streptococcal antibody score than that in control group and this score is also higher than that in CPP group (P<0.05); anti-streptococcal antibody score of patients with AGP in progressive stage is not significantly higher than that in remission stage (P>0.05). No statistical differences in the anti.staphylococcal and anti-Candida albicans antibody score were observed between AGP and control group (P>0.05). The immune reponse to streptococcus in patients with AGP using intradermal test of inactivated streptococci was also studied, 26 of 40 patients presented positive results. Our results prove that streptococcal infections are closely correlated with the onset of acute guttate psoriasis.

Key words: Psoriasis, Streptococcal infections, Immunoblotting