中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (2): 111-112.

• 论著 • 上一篇    下一篇

银屑病患者皮损与非皮损区皮肤中蛋白激酶C活性

刘镇修1, 宗志宏2, 李炎夏1, 孙立1, 尹小青1, 于秉治2   

  1. 1. 解放军二O五医院皮肤科 辽宁锦州 121001;
    2. 中国医科大学生化教研室
  • 收稿日期:1996-07-12 修回日期:1996-11-13 出版日期:1997-04-15 发布日期:1997-04-15

The Activity of Protein Kinase C in Involved and Uninvolved Skin of Patients with Psoriasis

Liu Zhenxiu1, Zong Zhihong2, Li Yanxia1   

  1. No 205 Hospital of PLA, Jinzhou 121001
  • Received:1996-07-12 Revised:1996-11-13 Online:1997-04-15 Published:1997-04-15

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摘要： 蛋白激酶C(PKC)是一种钙离子活化,磷脂依赖性蛋白激酶.PKC与细胞增殖,癌变的关系极为密切,为了探讨PKC与银屑病之间的关系,对15例进行期寻常型银屑病患者的受累皮肤和未受累皮肤以及正常人皮肤的胞浆、胞膜中的PKC的活性分别进行了测定.结果表明:不论胞浆、胞膜、受累皮肤和未受累皮肤中PKC的比活性均明显高于正常皮肤,经统计学处理,有非常显着性差异.说明在银屑病中PKC存在明显的膜转移(translocation),提示:银屑病的发病机理与PKC有直接关系.

关键词: 蛋白激酶C, 银屑病

Abstract: Protein kinase C(PKC) is a calcium.activated and phospholipid.dependant protein kinase. PKC is closely related to the cell proliferation and carcinogenesis. The activity of PKC in the cytoplasm and cell membrane of the epidermis of lesional skin and uninvolved skin of 15 patients with psoriasis and healthy persons was defermined respectively. The results showed that the specific activity (pmol/mg/min) of PKC was significantly higher (P<0.01) in the cytoplasm and cell membrane of the epidermis of involved and uninvolved skin of patients with psoriasis than that of in healthy persons. The results showed that there is translocation of PKC in psoriasis, and the pathogenesis of psoriasis is closely related with PKC activity.

Key words: Protein kinase C, Psoriasis