中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (2): 108-110.

• 论著 • 上一篇    下一篇

银屑病患者血浆和皮损纤维连接蛋白含量测定及分子降解状态的研究

陈扬1, 郑茂荣2, 吕雁群3, 张永生3, 陈金妹3   

  1. 1. 解放军第九八医院皮肤科 湖州 313000;
    2. 第二军医大学长海医院皮肤科;
    3. 实验诊断科
  • 收稿日期:1996-09-16 修回日期:1997-01-30 出版日期:1997-04-15 发布日期:1997-04-15

Determination of Plasma and Lesional Fibronectin and Study on the Status of Molecular Degradation in Patients with Psoriasis

Chen Yang1, Zheng Maorong2, Lü Yanqun3   

  1. Department of Dermatology, No. 98 Hospital of PLA, Huzhou 313000
  • Received:1996-09-16 Revised:1997-01-30 Online:1997-04-15 Published:1997-04-15

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摘要： 为了探讨银屑病患者血浆纤维连接蛋白(PFN)和皮损可溶性纤维连接蛋白(SFN)的存在状态,采用火箭电泳法和蛋白印迹法分别对90例银屑病PFN和20例银屑病斑块状皮损SFN进行检测.结果表明,患者组PFN水平显着低于正常人对照组,皮损SFN含量明显高于正常人皮肤.扫描结果提示,患者组PFN降解增强可能是PFN减少的主要原因,不同期银屑病组PFN降解程度有差异.皮损SFN增多可能是由于局部合成增加及PFN向表皮渗漏所致.动态观察银屑病患者PFN分子降解状态,具有重要的临床意义.

关键词: 银屑病, 纤维连接蛋白, 蛋白印迹法

Abstract: In order to study the status of existence of plasma fibronectin (PFN) and lesional soluble fibronectin (SFN) in patients with psoriasis, the levels of PFN and lesional SFN were detected by rockect electrophoresis and Western blot in 90 patients with psoriasis vulgaris and 20 patients with plaque psoriasis respectively. The results showed that in comparison with the control group, the level of PFN in psoriasis group decreased significantly; the content of SFN in psoriatic plaque was significantly higher than that in the normal human skin. Scanning (scanning densitometer) results indicated that the enhanced degradation of PFN in psoriatic group might be the main reason of reduced level of PFN. The extent of PFN degradation was different in different stages of the disease in psoriatic group. The increase of lesional SFN might be caused by increased local fibronectin synthesis and effusing of PFN into the epidermis. Dynamic observation of PFN molecular degradation may be of important clinical significance in patients with psoriasis.

Key words: Psoriasis, Fibronectin, Western blot