中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (2): 88-89.

• 论著 • 上一篇    下一篇

银屑病患者血浆β-内啡肽测定及其临床意义

刘翠杰, 刘华昌, 高秀芬, 靖立美   

  1. 济南军区总医院皮肤科, 济南 250031
  • 收稿日期:1995-04-04 修回日期:1995-06-26 出版日期:1996-04-15 发布日期:1996-04-15

Detection of Serum Beta-endorphin and its Clinical Significance in Patients with Psoriasis

Liu Cuijie, Liu Huachang, Gao Xiufen   

  1. Department of Dermatology, Jinan Military General Hospital, Jinan 250031
  • Received:1995-04-04 Revised:1995-06-26 Online:1996-04-15 Published:1996-04-15

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摘要： 为了探讨β-内啡肽(β-EP)在银屑病发病中的作用机理,采用放射免疫分析法对51例银屑病患者外周血β-EP水平进行了检测,并与32例健康体检者对照。结果显示:银屑病患者血浆β-EP水平明显高于对照组,即使达到临床治愈时,β-EP水平有所下降,但仍高于对照组;发病前有诱因者较无诱因者β-EP水平有增高趋势,但无统计学意义;皮损瘙痒的强度与血浆β-EP水平之间呈显着负相关。结论:β-EP参与银屑病的发病过程,其分泌既受中枢神经系统控制,又受皮损内炎症反应的影响,β-EP水平与皮损内炎症反应之间可能互为因果。

关键词: 银屑病, 内啡肽类

Abstract: In order to study the possible role of beta-endorphin (β-EP) in the pathogenesis of psoriasis, serum β-EP was detected by radioimmunoassay in 51 patients with psoriasis and 32 healthy controls. The results showed that serum β-EP level was markedly increased in patients with psoriasis in comparison with healthy controls. The serum β-EP level was reduced when the skin lesions of the patients were cleared after treatment, however, it was still higher than in healthy controls. Although there was a tendency towards an increase of β-EP in patients with precipitating factors in comparison with those without precipitating factors, their levels were not significantly different. There was a negative correlation between the intensity of pruritus and β-EP levels. It is suggested that β-EP involves in the pathogenisis of psoriasis. Its production and release were controlled by the central nervous system and also affected by the inflammation of skin lesions. There might be a causality between β-EP levels and inflammatory reaction of skin lesions.

Key words: Psoriasis, Endorphins