中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (2): 80-82.

• 论著 • 上一篇    下一篇

银屑病患者HLA-DR基因分型的研究

刘述文1, 李恒进2, 陈香美1, 虞瑞尧2   

  1. 1. 解放军总医院肾科, 北京, 100853;
    2. 解放军总医院皮肤科, 北京, 100853
  • 收稿日期:1994-06-14 修回日期:1994-12-09 出版日期:1995-04-15 发布日期:1995-04-15

HLA-DR Genotyping Using Polymerase Chain Reaction and Sequence-Specific Oligonucleotide Probes in Patients with Psoriasis

Liu Shuwen1, Li Hengjin2, Chen Xiangmei1   

  1. Department of Nephrology, General Hospital of Chinese PLA, Beijing 100853
  • Received:1994-06-14 Revised:1994-12-09 Online:1995-04-15 Published:1995-04-15

摘要: 利用多聚酶链反应技术及序列特异性寡核苷酸探针对30例银屑病患者进行了HLA-DR基因分型,并与255例北方汉族正常人HLA-DR基因频率进行了比较.发现HLA-DR7基因频率在银屑病患者较正常对照组明显增高(25.0:14.5,Pc<0.05,RR=2.446),而HLA-DR9基因频率却较正常对照组明显降低(3.33:12.4,Pc<0.05,RR=0.218).提示银屑病致病基因与HLA-DR7关联.

关键词: 银屑病, 人白细胞抗原

Abstract: HLA-DR gene frequency was obtained using polymerase chain reaction (PCR) and sequence-specific oligonucleotide (SSO) probes in 30 patients with psoriasis.Comparison of the HLA-DR gene frequency between the 30 patients and 255 normal controls showed that: HLA-DR7 gene frequency was significantly increased in the patients (25.0 vs 14.5,Pc<0.05,RR=2.446), while HLA-DR9 gene frequency was obviously decreased in the patients (3.33 vs 12.4, Pc<0.05,RR=0.218).The results showed that the psoriatic pathogenic gene might be closely related to the HLA-DR7 alleles.

Key words: Psoriasis, HLA antigens