中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (2): 77-79.

• 论著 • 上一篇    下一篇

寻常型银屑病患者表皮细胞DNA含量检测及其临床意义

朱可建, 朱铁城   

  1. 浙江医科大学附属第二医院皮肤科, 杭州, 310009
  • 收稿日期:1994-06-09 修回日期:1994-11-28 出版日期:1995-04-15 发布日期:1995-04-15

Detection of Epidermal Cellular DNA Content and its Clinical Significance in Psoriasis Vulgaris

Zhu Kejian, Zhu Tiecheng   

  1. Department of Dermatology, Second Affiliated Hospital, Zhejiang Medical University, Hangzhou 310009
  • Received:1994-06-09 Revised:1994-11-28 Online:1995-04-15 Published:1995-04-15

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摘要： 用流式细胞仪检测14例正常皮肤和36例寻常型银屑病患者皮损及非皮损的表皮细胞DNA含量.结果表明,表皮细胞增殖活性在止常皮肤、银屑病非皮损和皮损中依次增高,且差异有显着性(P<0.01).结合临床、组织病理和6例患者治疗前后自身对比,对以上改变的临床意义提出讨论.

关键词: 银屑病, 脱氧核糖核酸

Abstract: Detection of epidermal cellular DNA content by flow cytometry was performed in normal skin of 14 individuals, both lesiona] and nonlesional areas of 36 patients with psoriasis vulgaris.The results showed that the proliferative activity of epidermal cells was increased successively in normal skins, nonlesional and lesional skin of patients.The differences were significant (P<0.01).In combination with the clinical features and histopathological changes and the comparison of 6 patients before and after treatment, the clinical significance of above changes has been discussed.

Key words: Psoriasis, DNA