中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (2): 72-74.

• 论著 • 上一篇    下一篇

银屑病患者血小板指数及血浆脂质过氧化的研究

李冠勇1, 刘华昌1, 赵喜荣2, 周春蕾1, 季军捷3   

  1. 1. 济南军区总医院皮肤科, 济南, 250031;
    2. 全军临床药理基地中心实验室;
    3. 自动血液分析仪研究室
  • 收稿日期:1994-06-16 修回日期:1994-09-24 出版日期:1995-04-15 发布日期:1995-04-15

Investigation of Platelet Indexes and Plasma Lipid-Peroxidation in Patients with Psoriasis

Li Guanyong1, Liu Huachang1, Zhao Xirong2   

  1. Department of Dermatology, Jinan Military General Hospital, Jinan 250031
  • Received:1994-06-16 Revised:1994-09-24 Online:1995-04-15 Published:1995-04-15

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摘要： 检测了银屑病患者血小板三项指数、血浆丙二醛及谷胱甘肽过氧化物酶水平,与健康组相比,银屑病患者平均血小板体积、血小板体积分布宽度及丙二醛水平增高(P均<0.01),而谷胱甘肽过氧化物酶活性降低(P<0.05).平均血小板体积、血小板体积分布宽度及两二醛异常程度与病期及皮损范围有关,说明血小板及脂质过氧化反应异常在银屑病发病中发挥了一定作用.综合分析平均血小板体积、血小板体积分布宽度、丙二醛及谷胱甘肽过氧化物酶水平可作为判断病情和估计疗效的重要参考指标.

关键词: 银屑病, 血小板, 过氧化脂质类

Abstract: This article reports three indexes of platelet,plasma malonyldialdehyde (MDA) content and glutathione-peroxidase (GSH px) activity in patients with psoriasis.Compared with normal subjects, the levels of mean platelet volume (MPV), platelet distribution width (PDW) and MDA in the patients were higher (P<0.001, P<0.001, P<0.002 respectively) while the activity of GSH-px was lower (P<0.05).The degree of abnormality of MPV, PDW and MDA was correlated with the stage of disease and the extent of involvement, which suggests that abnormality of platelet and lipid-peroxidation may play a certain role in the pathogenesis of psoriasis.Comprehensive analysis of levels of MPV, PDW, MDA and GSH-px may be sed as important reference indexes to judge the seventy of the disease and evaluate the therapeutic eftect.

Key words: Psoriasis, Blood platelet, Lipid peroxides