中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (2): 70-71.

• 论著 • 上一篇    下一篇

银屑病皮损表皮中表皮生长因子的免疫组化研究

黄长征, 王椿森   

  1. 武汉同济医科大学附属协和医院皮肤科, 430022
  • 收稿日期:1994-06-22 修回日期:1994-10-22 出版日期:1995-04-15 发布日期:1995-04-15

Immunohistochemical Study of Epidermal Growth Factor in Lesional Epidermis of Psoriasis

Huang Changzheng, Wang Chunsen   

  1. Department of Dermatology, Union Hospital, Tongji Medical University, Wuhan 430022
  • Received:1994-06-22 Revised:1994-10-22 Online:1995-04-15 Published:1995-04-15

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摘要： 用一种新的免疫组化技术标记的抗生蛋白链菌素-生物素连接系统对24例银屑病患者皮损及10例正常人表皮中的表皮生长因子进行了免疫组化研究.结果表皮生长因子阳性染色细胞主要分布于棘层和颗粒层.银屑病患者表皮生长因子阳性表达率为75%.表皮生长因子阳性表达率及阳性细胞密度在静止期与进行期之间及初发病例与复发病例之间均无统计学差异(P均>0.05).

关键词: 银屑病, 表皮生长因子

Abstract: Immunohistochemical study was carried out for epidermal growth factor (EGF) in the epidermis from 24 patients with psoriasis and 10 normal controls with a new immunohistochemical techniquelabelled streptavidin biotin system.The results showed that the EGF positive staining cells were mainly localized in the stratum spinosum and stratum granulosum.The positive percentage of EGF expression in the patients is 75%.The percentage and the density of positive cells had no statistical difference either between the epidermis of the patients in stable stage and progressive stage or cases of first onset and relapsed ones (P>0.05).

Key words: Psoriasis, Epidermal growth factor