中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (6): 347-348,399.

• 论著 • 上一篇    下一篇

大疱性系统性红斑狼疮的皮肤基底膜带相关抗原

张学军1, 翁孟武2, 施守义2   

  1. 上海医科大学皮肤病学研究所, 200040
  • 收稿日期:1993-11-27 修回日期:1994-04-22 发布日期:1994-12-15

Related Antigens of Skin Basement Membrane Zone in Bullous Systemic Lupus Erythematosus

ZHANG XueJun1, WENG Meng-Wu2, SHI Shou-Yi2   

  1. Institute of Dermatology, Shanghai Medical University, Shanghai 200040
  • Received:1993-11-27 Revised:1994-04-22 Published:1994-12-15

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摘要： 免疫印迹和盐裂皮肤间接免疫荧光检测5例大疱性系统红斑狼疮(BSLE)血清,对照为5例获得性大疤性表皮松解症(EBA)、20例类天疱疮(BP)、20例SLE和10例正常人血清.结果表明,3例(3/5)BSLE血清结合盐裂皮肤真皮侧和真皮提取物中290 000抗原,其中2例BSLE血清也结合表皮提取物中165000抗原,结果与 EBA和部分BP血清相同.SLE血清未结合 290000和165000抗原.提示BSLE血清中存在EBA和BP抗体,推测EBA和BP抗原可能是BSLE的皮肤基底膜带相关抗原.

关键词: 红斑狼疮, 系统性, 基底膜, 抗原

Abstract: Using immunoblotting analysis and salt-split skin indirect immunofluorescence, we studied sera from 5 patients with bullous systemic lupus erythematosus (BSLE) and 55 control subjects,including 20 cases of SLE, 20 cases of bullous pemphigoid (BP),5 cases of epidermolysis bullosa acquisita (EBA) and 10 normal volunteers.The results showed that the sera from 3 of 5 BSLE patients combined with dermal side of saltsplit skin and 290 000 antigen of dermal extracts in human skin.Sera from 2 BSLE patients which reacted with 290 000 antigen also combined with 165 000 antigen of epidermal extracts.Sera from SLE patients did not combined with both 290 000 and 165 000 antigens.The results suggest that there are EBA antibody and BP antibody in BSLE.We consider that EBA antigen and BP antigen may be the related antigens of skin basement membrane zone in BSLE.

Key words: Lupus erythematosus, systemic, Basilar membrane, Antigen