中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (6): 331-333.

• 论著 • 上一篇    下一篇

银屑病患者尿中四种多胺的检测

李俊杰1, 罗汉超2   

  1. 1. 四川沪州医学院附属暖院皮肤科 511700;
    2. 华西医科大学附属第一医院
  • 收稿日期:1992-09-22 修回日期:1993-02-19 出版日期:1993-12-15 发布日期:1993-12-15

Detertmination of Polyamines in Urine of Patients with Psoriasis and Its Clinical Significance

LI Jun-jie1, LUO Han-Chao2   

  1. Affiliate d Hospital, Luzhou Medical College, Luzhou, Sichuan Province 646000
  • Received:1992-09-22 Revised:1993-02-19 Online:1993-12-15 Published:1993-12-15

PDF (PC)

288

赞

摘要： 采用反向高效液相色谱分析法检测了60例银屑病患者的晨尿,正常人42例晨尿和40例24小时尿中多胺含量.结果发现正常人24小时尿与晨尿中多胺含量无显著性差异,患者晨尿中四种多胺均较对照组显著性上升.不同病期的腐胺.尸胺、精脒以及精脒/精胺比值有显著性差异;治疗后腐胺、尸胺,精眯显著性下降;地图状皮损尿腐胺显著性升高,炎症重者腐胺、精眯上升更明显.晨尿中多胺含量可作为银屑病病情判断和疗效观察的生化指标.

关键词: 银屑病, 尿聚胺

Abstract: The levels of polyamines in the morning urine from 60 patients with psoriasis and 42 normal persons and 24-hour urine from 40 normal persons were determined by high performance Liquid chromtography.The resalts showed:No significant differences were noted between polyamine levels in 24-hour urine and those in the morning urine.The levels of putrescinc(PU),cadaverine(CA),spcrmidine(5D) and spermine(SM) in the urine from patients were significantly higher than those of rnntrol subjects(P<0.01).The levels of PU,CA,SD and SD:SM ratio had aignificant differences among different stages of the disease(P< 0.01,0.01,0.01,0.05,respectively).Effective treatment also significantly reduced the levels of PU,CA and SD in the urine(P<0.05,0.05,0.01 respectively).The urine from patients with map-shaped lesions had significantly high PU levels.The levels of PU,SD and SD:SM ratio were higher in the urine from patients wah severe inflamoratory lesions than those with otlicr conditions.The measurement of the levels of polyamines in the extorning urine may offer an approach to assess the severity and the effcacy of treatment.

Key words: Psoriasis, Urine, Polyamines