中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (4): 232-234.

• 论著 • 上一篇    下一篇

银屑病患者血和皮损处血小板活化因子生物测定

  

  1. 1. 第二军医大学长海医院皮肤科, 上海, 200433;
    2. 第二军医大学病理生理教研室
  • 收稿日期:1991-04-16 修回日期:1991-07-11 出版日期:1992-08-15 发布日期:1992-08-15

Identification and quantitation of platelet activating factor (PAS) in the blood and the skin of psoriatic patients and its clinical significance

LIU Bao-Jun   

  1. Ghanghai Hospital, The Second Military University, Shanghai, 200433
  • Received:1991-04-16 Revised:1991-07-11 Online:1992-08-15 Published:1992-08-15

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摘要： 用洗涤兔血小板生物方法测定了27例银屑病患者血及皮损处皮肤(含表皮和真皮)中血小板活化因子(PAF)含量.提取物经4种方法鉴定证实含有PAF.结果表明皮损处皮肤中PAF平均含尾为1.919ng/100mg组织,且与银屑病病情活动有关.银屑病患者血和正常人血及皮肤中均未测出PAF.提示PAF作为强效炎症介质对银屑病皮损的发生及持续存在起一定作用.

关键词: 银屑病, 血小板激活因子

Abstract: The PAF levels in the blood and the skin including epidermis and dermis from 27 cases of psoriasis were determined by using the aggregation of washed rabbit platelets. Four kinds of charaeterizations confirmed the existence of PAF in the exudate. The results showed that the PAF level in the involved skin was 1.923ng/100mg, and correlated to the disease activity of psoriasis. The PAF was not detected in the blood of psnriatic patients and the blood and skin of normal contrnls.It is suggested that tie PAF as a potential mediator of inflammatory reactions probably had some effects on the development and persistence of the skin lesion in psoriasis.

Key words: Psoriais, Platelet activating factor