中华皮肤科杂志 ›› 2018, Vol. 51 ›› Issue (1): 5-9.doi: 10.3760/cma.j.issn.0412-4030.2018.01.002
潘萌,郑捷
收稿日期:2017-09-18
修回日期:2017-10-12
出版日期:2018-01-15
发布日期:2018-01-11
通讯作者:
潘萌
E-mail:panmeng2000@yahoo.com
基金资助:天疱疮患者T-B细胞相互作用的分子机制及CD19hiICAM-1hiB细胞对抗体产生的影响;天疱疮皮损异位淋巴结构的形成及长链非编码RNA调控机制的研究;天疱疮皮损局部B细胞的作用截止;外用药物治疗天疱疮的临床和作用机制研究
,Jie ZHENG
Received:2017-09-18
Revised:2017-10-12
Online:2018-01-15
Published:2018-01-11
摘要：
寻常型天疱疮（pemphigus vulgaris，PV）是一累及皮肤与黏膜的自身免疫性皮肤病，属于表皮内大疱病，临床上较常见，可表现为广泛的红斑、松弛的水疱及糜烂、结痂面，尼氏征阳性。患者血清中存在针对桥粒黏蛋白1（desmoglein1，Dsg1，相对分子质量160 000）和（或）抗桥粒黏蛋白3（desmoglein3，Dsg3，相对分子质量130 000）的IgG型抗体［1］，该抗体和自身抗原结合，导致细胞间连接破坏，棘层松解发生和表皮内水疱形成［2］。根据PV患者血清中存在的自身抗体类型，可以分为黏膜主导型（mucosal dominant）与皮肤黏膜型（mucocutaneous）……
中图分类号:
潘萌 郑捷. 寻常型天疱疮自身抗体检测及治疗方法的进展[J]. 中华皮肤科杂志, 2018, 51(1): 5-9.
Jie ZHENG. Detection of autoantibodies in and therapeutic methods of pemphigus vulgaris[J]. Chinese Journal of Dermatology, 2018, 51(1): 5-9.
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