寻常型银屑病皮损部位主要免疫相关细胞的研究进展

doi:10.35541/cjd.20191104

摘要/Abstract

摘要： 【摘要】寻常型银屑病是一种反复发作的炎症性皮肤病，多种因素，如外伤、感染等，可以破坏皮肤屏障功能，进而打破免疫自稳和免疫耐受平衡，使皮肤局部多种免疫相关细胞的功能和/或数量异常，引起皮损部位角质形成细胞异常增生及过度的炎症反应等银屑病性损害。皮损部位各种免疫细胞通过表面分子感受周围环境变化（自分泌或旁分泌）后，表达并分泌多种炎症相关因子，如果免疫自稳和免疫耐受的维持机制失效，则在局部形成由炎症相关因子介导的炎症正反馈网络，从而引发寻常型银屑病。本文从皮损部位免疫相关细胞的角度，特别是固有免疫细胞如γδT细胞等，综述寻常型银屑病的免疫病理机制研究进展。

关键词: 银屑病, 炎症, 角质形成细胞, 树突细胞, 固有免疫, T淋巴细胞, γδT细胞

Abstract: 【Abstract】 Psoriasis vulgaris is a recurrent inflammatory skin disease. A variety of factors, such as trauma and infection, can destroy the skin barrier function, thereby breaking the balance of immune homeostasis and tolerance, causing abnormal function and/or number of various immune-related cells in local skin, resulting in psoriasis-like skin changes such as abnormal proliferation of keratinocytes and excessive inflammatory reactions in skin lesions. Various immune cells in skin lesions can sense changes in the surrounding environment （autocrine or paracrine） through surface molecules, and then express and secrete a variety of inflammation-related factors; if maintenance mechanisms for immune homeostasis and tolerance become invalid, the positive feedback network of inflammation mediated by inflammation-related factors will be formed locally, leading to the occurrence of psoriasis vulgaris. This review summarizes research progress in the role of immune-related cells in skin lesions in the immunopathological mechanism of psoriasis vulgaris, especially innate immune cells such as γδT cells.

Key words: Psoriasis, Inflammation, Keratinocytes, Dendritic cells, Innate immunity, T-lymphocytes, γδT cell

林路洋陈政良张锡宝. 寻常型银屑病皮损部位主要免疫相关细胞的研究进展[J]. 中华皮肤科杂志, 2021, 54(9): 830-834.doi:10.35541/cjd.20191104

Lin Luyang, Chen Zhengliang, Zhang Xibao. Major immune-related cells in psoriasis vulgaris lesions[J]. Chinese Journal of Dermatology, 2021, 54(9): 830-834.doi:10.35541/cjd.20191104

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