治疗性皮肤创伤诱导白癜风皮损复色的机制与临床研究进展

doi:10.35541/cjd.20190876

中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (3): 267-269.doi: 10.35541/cjd.20190876

治疗性皮肤创伤诱导白癜风皮损复色的机制与临床研究进展

廖志锴,雷铁池

武汉大学人民医院皮肤科 430060

收稿日期:2019-09-05 修回日期:2020-03-31 发布日期:2021-03-02
通讯作者: 雷铁池 E-mail:tiechilei@126.com
基金资助:
国家自然科学基金（81573028、81972919）

Therapeutic trauma-induced repigmentation of vitiligo lesions: mechanisms and relevant clinical studies

Liao Zhikai, Lei Tiechi

Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan 430060, China

Received:2019-09-05 Revised:2020-03-31 Published:2021-03-02
Contact: Lei Tiechi E-mail:tiechilei@126.com
Supported by:
National Natural Science Foundation of China（81573028、81972919）

摘要/Abstract

摘要： 【摘要】人们很早就注意到用皮肤磨削术、中医梅花针或皮肤微针，甚至剥脱性点阵CO2激光等对常规中波紫外线光疗抵抗的白癜风皮损可有效诱导复色。这些治疗除了因创伤增加药物透皮吸收外，还启动了创伤修复以及对毛囊或表皮黑素细胞的活化。伤口周围基底层角质形成细胞、血管内皮细胞和成纤维细胞分泌趋化因子12以招募毛囊隆突区或皮损周围表达趋化因子受体CXCR4/CXCR7的黑素细胞或黑素干细胞向白斑区移行。本文综述治疗性皮肤创伤诱导白癜风皮损复色的研究进展。

关键词: 白癜风, 趋化因子CXCL12, 黑素细胞, 治疗性创伤, 复色

Abstract: 【Abstract】 It has long been noted that dermabrasion, plum-blossom needling or micro-needling, and even ablative fractional CO2 laser are effective for repigmentation of vitiligo lesions resistant to conventional ultraviolet B phototherapy. In addition to trauma-induced increase in the transdermal absorption of drugs, these treatments also initiate wound repair and activate melanocytes in hair follicles or epidermis. Basal layer keratinocytes, vascular endothelial cells and fibroblasts in the wound margins can secrete chemokine CXCL12 to recruit melanocytes or melanocyte stem cells expressing chemokine receptors CXCR4/CXCR7 in the hair follicle bulge or around the skin lesions to move towards the vitiliginous area. This review summarizes progress in repigmentation of vitiligo lesions induced by therapeutic skin trauma.

Key words: Vitiligo, Chemokine CXCL12, Melanocyte, Therapeutic trauma, Repigmentation

廖志锴雷铁池. 治疗性皮肤创伤诱导白癜风皮损复色的机制与临床研究进展[J]. 中华皮肤科杂志, 2021,54(3):267-269. doi:10.35541/cjd.20190876

Liao Zhikai, Lei Tiechi. Therapeutic trauma-induced repigmentation of vitiligo lesions: mechanisms and relevant clinical studies[J]. Chinese Journal of Dermatology, 2021, 54(3): 267-269.doi:10.35541/cjd.20190876

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治疗性皮肤创伤诱导白癜风皮损复色的机制与临床研究进展

Therapeutic trauma-induced repigmentation of vitiligo lesions: mechanisms and relevant clinical studies

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