Chinese Journal of Dermatology ›› 1994, Vol. 27 ›› Issue (3): 141-143,189.

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Study on Chromosomal Fragile Sites of Lymphocytes in Patients with Neuroribromatosis

ZHENG Li-Fang1, LIU Xiao-Yin1, CAO Zhi-Xiang2   

  1. Department of Medical Genetics, Qiqihar Medical College, Qiqihar 161041
  • Received:1993-05-20 Revised:1993-10-05 Online:1994-06-15 Published:1994-06-15

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Abstract: The rates of chromosome aberration and fragile site expres.sion in lymphocytes of 20 patients with neurofibromatosis and the normal control were studied.The results showed that the fragile site expression was 14.50% in patients and 2.40% in the controls respectively,and the rates of chromosome aberratioll were 15.90% in patients,but 2.45% in the controls.The chromosome aberration rates and fragile sites of patients were significantly higher than those of the controls (P<0.005).Some fragile sites in patients were at the loci of cancer breakpoints and oncogenes.The findings indicate that the fragile sites are important in the pathogenesis of neurofibromatosis.

Key words: Neurofibroma, Chromosome fragile sites