Abstract: Objective To investigate the variation of clinical manifestations in adult patients with atopic dermatitis (AD) in the past decade.Methods 323 AD adult patients were included in this study and they were divided into two groups.Group A(162 cases) were diagnosed in the mid 1990s;and group B(161 cases) in early 1980s.The patterns,distrbution and the areas involved of skin lesions were studied,respectively.Results The eczematous and lichenified lesions were predominant in both groups.In group A,the eczemtous lesions (49 4%) were more than the lichenified lesions(45.7%);but in group B,the latter (58.4%) was more than the former (39.1%).The lesions distributed more on the extremities,and the areas involved were less than 25% of the body surface.There were no statistical differences in the clinical manifestations between two roups.Conclusion There were no variations in clinical manifestations of adult AD in the past decade,the clinical course was rather mild,and the eczematous lesions slightly increased.

Key words: Dermatitis, atopic