Abstract: 【Abstract】 The pathogenesis of atopic dermatitis （AD） has not been fully elucidated, which may be mainly associated with abnormality of immunity, dysfunction of skin barrier and environmental factors. The main symptom of AD is severe pruritus, which can greatly affect the life quality of patients. The management of AD in clinical practice is still a big challenge. Most patients can achieve improvement through avoidance of provocative factors, basic skin care and topical application of anti-inflammatory agents. However, a few patients with generalized lesions are resistant to conventional therapy, and systemic therapy is needed. Biological agents have been widely used in patients with moderate and severe AD. This review summarizes advances in the medications for AD.

Key words: Dermatitis, atopic, Therapies, investigational, Biological therapy