Abstract: Several years after trauma,a patient suffered from skin verrucous hyperplasia for more than 30 years,accompanied by ulcer occasionally,on the feet,ankles and legs successively.Mycological examination (9 times) had been done before treatment.Slight septate hyphae and/or spores were demonstrated by directmicroscopy(5 times);and yellowish greencolony grewon Sabouraud agarat 25℃ for 2 times,it was identified as Epidermophyton floccosum.Yeast-like colony grew on Sabourau dagar at 25℃ for 5 times,it was identi fied as Candida ciferrii by API.After treatment,Candida ciferrii could still be detected by mycological examination(6 times),but no Epidermophyton floccosum was found.Slight septate hyphae were demonstrated in stratum spinosum,stratum granulosum and stratum corneum by histopathological examination.Isolated or clustered blastospores,spores and chlamydospores were demonstrated in stratum corneum by histopathological examin ation.Therefore,it was concluded that the skin verrucous hyperplasia in this case is caused by mixed infection of Epidermophyton floccosum and Candida ciferrii.The patient was treated with flucon azole capsule 50mg daily for 5weeks,followed by terbinafine tablet 250 mg daily for 36 weeks,and then 250 mg twice daily for 18weeks.In the 5th week of terbinafine therapy,a part of the lesions on the shin of left leg healed.No further therapeutic effect was observed.

Key words: Epidermophyton floccosum, Candida ciferrii, Hyperplasia, Skin