Chinese Journal of Dermatology ›› 2025, Vol. 58 ›› Issue (6): 567-572.doi: 10.35541/cjd.20240419
• Reviews • Previous Articles Next Articles
Liang Gaopeng, Yang Xianjie, Chen Qiquan, Song Zhiqiang
Received:
2024-08-07
Revised:
2025-04-08
Online:
2025-06-15
Published:
2025-06-03
Contact:
Song Zhiqiang
E-mail:drsongzq@tmmu.edu.cn
Supported by:
Liang Gaopeng, Yang Xianjie, Chen Qiquan, Song Zhiqiang. Comorbidities of chronic urticaria[J]. Chinese Journal of Dermatology, 2025, 58(6): 567-572.doi:10.35541/cjd.20240419
[1] | Fricke J, Ávila G, Keller T, et al. Prevalence of chronic urticaria in children and adults across the globe: systematic review with meta⁃analysis[J]. Allergy, 2020,75(2):423⁃432. doi: 10.1111/all.14037. |
[2] | Maurer M, Abuzakouk M, Bérard F, et al. The burden of chronic spontaneous urticaria is substantial: real⁃world evidence from ASSURE⁃CSU[J]. Allergy, 2017,72(12):2005⁃2016. doi: 10. 1111/all.13209. |
[3] | Staubach P, Mann C, Peveling⁃Oberhag A, et al. Epidemiology of urticaria in German children[J]. J Dtsch Dermatol Ges, 2021,19(7):1013⁃1019. doi: 10.1111/ddg.14485. |
[4] | Papapostolou N, Xepapadaki P, Katoulis A, et al. Comorbidities of chronic urticaria: a glimpse into a complex relationship[J]. Front Allergy, 2022,3:1008145. doi: 10.3389/falgy.2022.1008145. |
[5] | Deng L, Yao Y, Lu Z, et al. Causal associations between chronic spontaneous urticaria and thyroid function indicators on different ethnic groups: a bidirectional two⁃sample mendelian randomization analysis[J]. Allergy, 2024. doi: 10.1111/all.16400. |
[6] | Kolkhir P, Bieber K, Hawro T, et al. Mortality in adult patients with chronic spontaneous urticaria: a real⁃world cohort study[J]. J Allergy Clin Immunol, 2025,155(4):1290⁃1298. doi: 10.1016/j.jaci.2024.11.036. |
[7] | Barzilai A, Baum A, Ben⁃Shoshan M, et al. Epidemiological and clinical characteristics of adult and pediatric patients with chronic spontaneous urticaria[J]. J Clin Med, 2023,12(23):7482. doi: 10.3390/jcm12237482. |
[8] | Conrad N, Misra S, Verbakel JY, et al. Incidence, prevalence, and co⁃occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population⁃based cohort study of 22 million individuals in the UK[J]. Lancet, 2023,401(10391):1878⁃1890. doi: 10.1016/S0140⁃6736(23)00457⁃9. |
[9] | Le M, Zhang L, Gabrielli S, et al. Increased prevalence of autoimmune diseases in children with chronic spontaneous urticaria[J]. Pediatr Allergy Immunol, 2022,33(2):e13736. doi: 10.1111/pai.13736. |
[10] | Kolkhir P, Altrichter S, Asero R, et al. Autoimmune diseases are linked to typeⅡb autoimmune chronic spontaneous urticaria[J]. Allergy Asthma Immunol Res, 2021,13(4):545⁃559. doi: 10. 4168/aair.2021.13.4.545. |
[11] | Magen E, Zueva E, Mishal J, et al. The clinical and laboratory characteristics of acute spontaneous urticaria and its progression to chronic spontaneous urticaria[J]. Allergy Asthma Proc, 2016,37(5):394⁃399. doi: 10.2500/aap.2016.37.3971. |
[12] | Tienforti D, Di Giulio F, Spagnolo L, et al. Chronic urticaria and thyroid autoimmunity: a meta⁃analysis of case⁃control studies[J]. J Endocrinol Invest, 2022,45(7):1317⁃1326. doi: 10.1007/s40618⁃022⁃01761⁃2. |
[13] | Gonzalez⁃Diaz SN, Sanchez⁃Borges M, Rangel⁃Gonzalez DM, et al. Chronic urticaria and thyroid pathology[J]. World Allergy Organ J, 2020,13(3):100101. doi: 10.1016/j.waojou.2020.100101. |
[14] | Selvendran SS, Aggarwal N. Chronic urticaria and thyroid autoimmunity: a perplexing association[J]. Oxf Med Case Reports, 2018,2018(2):omx099. doi: 10.1093/omcr/omx099. |
[15] | Zysk W, Trzeciak M. Characterization of chronic urticaria and associated conditions ⁃ a web⁃based survey[J]. Dermatol Pract Concept, 2023,13(1):e2023056. doi: 10.5826/dpc.1301a56. |
[16] | Xiao M, Zhang X, Guo A, et al. A retrospective cohort study on the comorbidity in 19,264 Chinese patients of different ages with urticaria[J]. Acta Derm Venereol, 2024,104:adv24050. doi: 10.2340/actadv.v104.24050. |
[17] | Guo Y, Li HM, Zhu WQ, et al. Role of Helicobacter pylori eradication in chronic spontaneous urticaria: a propensity score matching analysis[J]. Clin Cosmet Investig Dermatol, 2021,14:129⁃136. doi: 10.2147/CCID.S293737. |
[18] | Sánchez Caraballo A, Guzmán Y, Sánchez J, et al. Potential contribution of Helicobacter pylori proteins in the pathogenesis of type 1 gastric neuroendocrine tumor and urticaria. In silico approach[J]. PLoS One, 2023,18(4):e0281485. doi: 10.1371/journal.pone.0281485. |
[19] | Gu H, Li L, Gu M, et al. Association between Helicobacter pylori infection and chronic urticaria: a meta⁃analysis[J]. Gastroenterol Res Pract, 2015,2015:486974. doi: 10.1155/2015/486974. |
[20] | Watanabe J, Shimamoto J, Kotani K. The effects of antibiotics for Helicobacter pylori eradication or dapsone on chronic spontaneous urticaria: a systematic review and meta⁃analysis[J]. Antibiotics (Basel), 2021,10(2):156. doi: 10.3390/antibiotics 10020156. |
[21] | He L, Yi W, Huang X, et al. Chronic urticaria: advances in understanding of the disease and clinical management[J]. Clin Rev Allergy Immunol, 2021,61(3):424⁃448. doi: 10.1007/s12016⁃021⁃08886⁃x. |
[22] | Navarro⁃Triviño FJ, Ruiz⁃Villaverde R. Changes in liver viral load in hepatitis B virus infection during treatment of chronic urticaria with omalizumab: is there a pathophysiologic relationship between the 2 diagnostic entities?[J]. Actas Dermosifiliogr, 2022,113 Suppl 1:S20⁃S22. doi: 10.1016/j.ad.2021.09.001. |
[23] | Kanazawa K, Yaoita H, Tsuda F, et al. Hepatitis C virus infection in patients with urticaria[J]. J Am Acad Dermatol, 1996,35(2 Pt 1):195⁃198. doi: 10.1016/s0190⁃9622(96)90322⁃9. |
[24] | Tiotiu A, Jaussaud R. Successful treatment with omalizumab for cold urticaria in a patient with chronic hepatitis C virus infection[J]. Eur J Dermatol, 2022,32(5):640⁃641. doi: 10.1684/ejd. 2022.4324. |
[25] | Brar AK, Grace J. Urticaria and HIV infection: a case report[J]. Cureus, 2022,14(9):e29662. doi: 10.7759/cureus.29662. |
[26] | Iemoli E, Niero F, Borgonovo L, et al. Successful omalizumab treatment in HIV positive patient with chronic spontaneous urticaria: a case report[J]. Eur Ann Allergy Clin Immunol, 2017,49(2):88⁃91. |
[27] | 中华医学会皮肤性病学分会荨麻疹研究中心. 抗IgE疗法——奥马珠单抗治疗慢性荨麻疹专家共识[J]. 中华皮肤科杂志, 2021,54(12):1057⁃1062. doi: 10.35541/cjd.20210568. |
[28] | Chiu HY, Muo CH, Sung FC. Associations of chronic urticaria with atopic and autoimmune comorbidities: a nationwide population⁃based study[J]. Int J Dermatol, 2018,57(7):822⁃829. doi: 10.1111/ijd.14000. |
[29] | Pourali SP, Kohn AH, Jones ME, et al. Chronic spontaneous urticaria: a 16⁃year analysis of pediatric patient demographics, treatment patterns, and comorbidities[J]. Dermatol Online J, 2021,27(8)doi: 10.5070/D327854723. |
[30] | 苏畅, 隋秀丽, 刘瑞玲, 等. 奥马珠单抗治疗慢性自发性荨麻疹伴有其他过敏性疾病患者74例临床分析[J]. 中华皮肤科杂志, 2023,56(6):512⁃517. doi: 10.35541/cjd.20220931. |
[31] | 严彩蓉, 亓玉青, 隋秀丽, 等. 奥马珠单抗治疗儿童和老年慢性自发性荨麻疹患者的短期疗效及安全性[J]. 中国皮肤性病学杂志, 2024,38(1):40⁃44. doi: 10.13735/j.cjdv.1001⁃7089.202304062. |
[32] | Jo YH, Yoo HW, Kim SH, et al. Clinical characteristics and treatment response of chronic spontaneous urticaria according to age: a single⁃center Korean study[J]. Asian Pac J Allergy Immunol, 2022,40(4):374⁃378. doi: 10.12932/AP⁃050719⁃0594. |
[33] | Galletta F, Caminiti L, Lugarà C, et al. Long⁃term safety of omalizumab in children with asthma and/or chronic spontaneous urticaria: a 4⁃year prospective study in real life[J]. J Pers Med, 2023,13(7):1068. doi: 10.3390/jpm13071068. |
[34] | Konstantinou GN, Konstantinou GN. Psychological stress and chronic urticaria: a neuro⁃immuno⁃cutaneous crosstalk. a systematic review of the existing evidence[J]. Clin Ther, 2020,42(5):771⁃782. doi: 10.1016/j.clinthera.2020.03.010. |
[35] | Ghazanfar MN, Kibsgaard L, Thomsen SF, et al. Risk of comorbidities in patients diagnosed with chronic urticaria: a nationwide registry⁃study[J]. World Allergy Organ J, 2020,13(1):100097. doi: 10.1016/j.waojou.2019.100097. |
[36] | Weller K, Maurer M, Bauer A, et al. Epidemiology, comorbidities, and healthcare utilization of patients with chronic urticaria in Germany[J]. J Eur Acad Dermatol Venereol, 2022,36(1):91⁃99. doi: 10.1111/jdv.17724. |
[37] | Elçin A, Ayla G, Tuba Saadet Deveci B, et al. Stressful life events, psychiatric comorbidities and serum neuromediator levels in patients with chronic spontaneous urticaria treated with omalizumab[J]. Allergol Immunopathol (Madr), 2024,52(3):1⁃7. doi: 10.15586/aei.v52i3.1015. |
[38] | Beyaz S, Demir S, Oztop N, et al. Psychological burden of COVID⁃19 on mild and moderate chronic spontaneous urticaria[J]. Allergy Asthma Proc, 2021,42(4):e107⁃e115. doi: 10.2500/aap. 2021.42.210026. |
[39] | Tzur Bitan D, Berzin D, Cohen A. The association of chronic spontaneous urticaria (CSU) with anxiety and depression: a nationwide cohort study[J]. Arch Dermatol Res, 2021,313(1):33⁃39. doi: 10.1007/s00403⁃020⁃02064⁃3. |
[40] | Choi GS, Nam YH, Park CS, et al. Anxiety, depression, and stress in Korean patients with chronic urticaria[J]. Korean J Intern Med, 2020,35(6):1507⁃1516. doi: 10.3904/kjim.2019.320. |
[41] | Stadler PC, Marsela E, Kämmerer T, et al. Impact of allergic reactions and urticaria on mental health and quality of life[J]. Allergol Immunopathol (Madr), 2022,50(2):124⁃130. doi: 10. 15586/aei.v50i2.525. |
[42] | Gupta MA, Gupta AK. Chronic idiopathic urticaria and post⁃traumatic stress disorder (PTSD): an under⁃recognized comorbidity[J]. Clin Dermatol, 2012,30(3):351⁃354. doi: 10.1016/j.clindermatol.2012.01.012. |
[43] | Özkaya E, Babuna Kobaner G, Yılmaz Z, et al. Doxepin in difficult⁃to⁃treat chronic urticaria: a retrospective, cross⁃sectional study from Turkey[J]. Dermatol Ther, 2019,32(4):e12993. doi: 10.1111/dth.12993. |
[44] | Tan MG, Bailey A, Dorus B, et al. Clinical impacts of omalizumab on the psychiatric comorbidities of chronic spontaneous urticaria: a systematic review and meta⁃analysis[J]. J Drugs Dermatol, 2024,23(4):e116⁃e117. doi: 10.36849/JDD.7919. |
[45] | Gupta P, Bishnoi A, Bakshi S, et al. Chronic spontaneous urticaria and metabolic syndrome: a relationship conundrum[J]. Arch Dermatol Res, 2023,315(8):2445⁃2448. doi: 10.1007/s00403⁃023⁃02636⁃z. |
[46] | Reddy M, Kolalapudi SA, Praveen S, et al. Clinical and laboratory parameters of metabolic syndrome in chronic spontaneous urticaria: a cross⁃sectional study[J]. Indian Dermatol Online J, 2025,16(1):105⁃109. doi: 10.4103/idoj.idoj_945_24. |
[47] | Kaşıkçı EE, Özışık M, Bayrak Değirmenci P. Evaluation of antihistamine⁃refractory chronic urticaria patients who used biological agent treatment in terms of cardiovascular risk[J]. Postepy Dermatol Alergol, 2024,41(6):610⁃616. doi: 10.5114/ada.2024.145572. |
[48] | Wagner N, Berking C. Recognition and management of relevant comorbidities in chronic spontaneous urticaria[J]. Dermatologie (Heidelb), 2024,75(4):289⁃294. doi: 10.1007/s00105⁃024⁃05311⁃0. |
[49] | Ratliff JC, Barber JA, Palmese LB, et al. Association of prescription H1 antihistamine use with obesity: results from the National Health and Nutrition Examination Survey[J]. Obesity (Silver Spring), 2010,18(12):2398⁃2400. doi: 10.1038/oby. 2010.176. |
[50] | Martina E, Damiani G, Grieco T, et al. It is never too late to treat chronic spontaneous urticaria with omalizumab: real⁃life data from a multicenter observational study focusing on elderly patients[J]. Dermatol Ther, 2021,34(2):e14841. doi: 10.1111/dth.14841. |
[51] | Falay Gur T, Savas Erdogan S, Erdemir VA, et al. Effect of omalizumab use on glucose homeostasis in non⁃diabetic patients with chronic urticaria[J]. Cutan Ocul Toxicol, 2020,39(4):348⁃353. doi: 10.1080/15569527.2020.1818769. |
[52] | Sørensen S, Farkas DK, Vestergaard C, et al. Urticaria and the risk of cancer: a Danish population⁃based cohort study[J]. Br J Dermatol, 2024,191(5):706⁃712. doi: 10.1093/bjd/ljae264. |
[53] | Napolitano M, Patruno C. Chronic urticaria can be caused by cancer and resolves with its cure[J]. Allergy, 2018,73(8):1750⁃1751. doi: 10.1111/all.13477. |
[54] | Sutton KM, Wiggins M, Zaragoza R, et al. Chronic spontaneous urticaria as the presenting feature in a paediatric case of chronic myeloid leukaemia[J]. Pediatr Blood Cancer, 2024,71(3):e30846. doi: 10.1002/pbc.30846. |
[55] | Miletić AI, Habek D, Medić F, et al. Ovarian yolk sac tumor in a premenarchal girl[J]. Wien Med Wochenschr, 2023,173(3⁃4):70⁃73. doi: 10.1007/s10354⁃022⁃00996⁃1. |
[56] | Bauer AT, Gorzelanny C, Gebhardt C, et al. Interplay between coagulation and inflammation in cancer: limitations and therapeutic opportunities[J]. Cancer Treat Rev, 2022,102:102322. doi: 10. 1016/j.ctrv.2021.102322. |
[57] | Verdoodt F, Pottegård A, Dehlendorff C, et al. Antihistamine use and risk of ovarian cancer: a population⁃based case⁃control study[J]. Maturitas, 2019,120:47⁃52. doi: 10.1016/j.maturitas.2018. 11.014. |
[58] | Fritz I, Wagner P, Olsson H. Improved survival in several cancers with use of H(1)⁃antihistamines desloratadine and loratadine[J]. Transl Oncol, 2021,14(4):101029. doi: 10.1016/j.tranon.2021.101029. |
[59] | Liu P, Kroemer G, Kepp O. Histamine antagonists promote cancer immunosurveillance[J]. Oncoimmunology, 2023,12(1):2242211. doi: 10.1080/2162402X.2023.2242211. |
[60] | Cully M. Anti⁃histamines boost immunotherapy[J]. Nat Rev Drug Discov, 2022,21(1):17. doi: 10.1038/d41573⁃021⁃00204⁃6. |
[61] | Hayama K, Fujita H, Asai⁃Sato M, et al. Successful treatment of intractable chronic spontaneous urticaria with omalizumab in a patient with ovarian cancer[J]. Eur J Dermatol, 2021,31(1):100⁃101. doi: 10.1684/ejd.2020.3959. |
[62] | Navarro⁃Triviño FJ, Mérida⁃Fernández C, Linares⁃Gonzalez L, et al. Is omalizumab safe and effective in oncological patients?[J]. Dermatol Ther, 2019,32(6):e13115. doi: 10.1111/dth.13115. |
[63] | Staubach P, Bilo B, Fluhr JW, et al. UCOMB⁃real life data: treatment strategies for chronic urticaria patients with comorbidities[J]. J Dermatolog Treat, 2024,35(1):2329784. doi: 10.1080/09546634.2024.2329784. |
[64] | Ornek SA, Suroji Alkilinc A, Kızıltac U, et al. Effect of puberty, menstruation, pregnancy, lactation, and menopause on chronic urticaria activity[J]. J Cutan Med Surg, 2023,27(5):466⁃471. doi: 10.1177/12034754231191472. |
[65] | Zhang H, Wang M, Zhao X, et al. Role of stress in skin diseases: a neuroendocrine⁃immune interaction view[J]. Brain Behav Immun, 2024,116:286⁃302. doi: 10.1016/j.bbi.2023.12.005. |
[66] | Kocatürk E, Al⁃Ahmad M, Krause K, et al. Effects of pregnancy on chronic urticaria: results of the PREG⁃CU UCARE study[J]. Allergy, 2021,76(10):3133⁃3144. doi: 10.1111/all.14950. |
[1] | Qi-Quan CHEN Song Zhi-Qiang WANG Gang. Guidelines for the diagnosis and treatment of refractory chronic spontaneous urticaria in China (2025 edition) [J]. Chinese Journal of Dermatology, 2025, 58(6): 485-496. |
[2] | Tang Huiyang, Yang Zhi, Yang Xi, Yao Zhengqiu, Hao Fei, Chen Bangtao. Mechanistic studies on the involvement of trimethylamine oxide in the pathogenesis of chronic spontaneous urticaria [J]. Chinese Journal of Dermatology, 2025, 58(6): 515-522. |
[3] | Xiao Meng, Zhao Meiru, Zhang Xinmei, Zhang Junyan, Qi Yuqing, Wang Huiping. Disease burden in patients with chronic spontaneous urticaria: a single-center retrospective analysis [J]. Chinese Journal of Dermatology, 2025, 58(6): 530-535. |
[4] | Liang Bihua, Chen Ziyan, Li Huaping, Zou Hui, Lin Tianyi, Li Xiaofeng, Zhang Luoyu, Li Shengxin, Ou Shanshan, Chen Jiaoquan, Li Runxiang, Zhu Huilan. Analysis of serum inflammatory factors associated with antihistamine resistance in patients with chronic spontaneous urticaria using the Olink-targeted proteomics technology [J]. Chinese Journal of Dermatology, 2025, 58(6): 523-529. |
[5] | Qiu Li, Xiao Ting . Bruton′s tyrosine kinase inhibitors in the treatment of chronic spontaneous urticaria [J]. Chinese Journal of Dermatology, 2025, 58(6): 563-567. |
[6] | Ye Mingyu, Shi Yanting, Li Hao, Xiang Jie, Wang Song, Cao Hua. Clinical significance of serum galectin-9 levels in the evaluation of combined tumors in dermatomyositis patients [J]. Chinese Journal of Dermatology, 2025, 58(4): 328-333. |
[7] | Li Xiuzhen, Xu Xiulian. Effects of interleukin-23 inhibitors on psoriasis comorbidities [J]. Chinese Journal of Dermatology, 2025, 58(3): 268-272. |
[8] | Li Jiaming, Wang Peng, Kang Xiaojing. Ferroptosis mechanisms and related intervention measures in malignant skin tumors [J]. Chinese Journal of Dermatology, 2025, 0(3): 20240125-e20240125. |
[9] | Yue Shuzhen, Shu Ye, Luo Yangyang, Li Keyao, Zhang Yuanyuan, Tang Jianping, Wei Zhu. Efficacy and safety of omalizumab in the treatment of chronic urticaria in children: a retrospective study [J]. Chinese Journal of Dermatology, 2024, 57(4): 354-358. |
[10] | Tian Jing, Deng Sisi, Song Zhiqiang . A comparison of clinical characteristics between atopic and non-atopic prurigo nodularis [J]. Chinese Journal of Dermatology, 2024, 57(4): 331-337. |
[11] | Chen Yusha, Wang Sheng. Hereditary photosensitive dermatoses [J]. Chinese Journal of Dermatology, 2024, 57(3): 279-282. |
[12] | Xu Zhuohong, Zhou Xuyue, Hu Yu, Gu Heng. Role of mast cells in the pathogenesis of chronic spontaneous urticaria and advances in mast cell-targeted therapies [J]. Chinese Journal of Dermatology, 2024, 0(3): 20240291-e20240291. |
[13] | Guo Lei, Cao Chunyan, Fang Xiaoya, Feng Suying. Analysis of current status and risk factors of multidrug-resistant bacteria wound infections in patients with autoimmune bullous diseases [J]. Chinese Journal of Dermatology, 2024, 57(2): 155-160. |
[14] | Zhao Miaomiao, Yu Peiyao, Yang Haiqian, Yu Yingyao, Ma Li, Mou Wenjia, Shang Yuanyuan. Efficacy, safety, and factors influencing efficacy of omalizumab in the treatment of chronic spontaneous urticaria: a prospective, single-center study [J]. Chinese Journal of Dermatology, 2024, 57(12): 1091-1098. |
[15] | Xie Xinran, Zhang Lu, Du Dan, Li Xiaoxue, Li Yanmei, Jiang Xian. Comorbidities in atopic dermatitis [J]. Chinese Journal of Dermatology, 2024, 57(11): 1058-1063. |
|