间充质干细胞来源的外泌体在皮肤病中的作用

doi:10.35541/cjd.20220881

Abstract

Abstract: 【Abstract】 Mesenchymal stem cells are pluripotent stem cells with the potential to differentiate into various types of cells. Many studies have shown that mesenchymal stem cells primarily exert their biological functions through paracrine effects, which can be mediated by exosomes. Exosomes can carry DNA, RNA, lipids, and proteins, and introduce them into recipient cells to produce various biological effects. In recent years, a lot of studies have confirmed the therapeutic effects of mesenchymal stem cell?derived exosomes from various sources on skin diseases. This review summarizes the biological characteristics and functions of mesenchymal stem cell-derived exosomes and their roles in the treatment of skin diseases.

Key words: Exosomes, Mesenchymal stem cells, Therapy, Lupus erythematosus, systemic, Dermatitis, atopic, Psoriasis

Xu Zhuohong, Hu Yu, Gu Heng. Role of mesenchymal stem cell-derived exosomes in skin diseases[J]. Chinese Journal of Dermatology,2025,e20220881. doi:10.35541/cjd.20220881

References ［39］

［1］	Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells［J］. Science, 1999,284（5411）:143⁃147. doi: 10.1126/science.284.5411.143.
［2］	Xunian Z, Kalluri R. Biology and therapeutic potential of mesenchymal stem cell⁃derived exosomes［J］. Cancer Sci, 2020,111（9）:3100⁃3110. doi: 10.1111/cas.14563.
［3］	Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes［J］. Science, 2020,367（6478）:eaau6977. doi: 10.1126/science.aau6977.
［4］	Kusuma GD, Barabadi M, Tan JL, et al. To Protect and to preserve: novel preservation strategies for extracellular vesicles［J］. Front Pharmacol, 2018,9:1199. doi: 10.3389/fphar.2018. 01199.
［5］	Chen J, Chen J, Cheng Y, et al. Mesenchymal stem cell⁃derived exosomes protect beta cells against hypoxia⁃induced apoptosis via miR⁃21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation［J］. Stem Cell Res Ther, 2020,11（1）:97. doi: 10.1186/s13287⁃020⁃01610⁃0.
［6］	Lai RC, Chen TS, Lim SK. Mesenchymal stem cell exosome: a novel stem cell⁃based therapy for cardiovascular disease［J］. Regen Med, 2011,6（4）:481⁃492. doi: 10.2217/rme.11.35.
［7］	Sipos F, Mzes G. Controversies in therapeutic application of mesenchymal stem cell⁃derived secretome［J］. BIOCELL, 2022, 46（4）: 4.doi: 10.32604/biocell.2022.018200.
［8］	Toh WS, Lai RC, Zhang B, et al. MSC exosome works through a protein⁃based mechanism of action［J］. Biochem Soc Trans, 2018,46（4）:843⁃853. doi: 10.1042/BST20180079.
［9］	Tang XD, Shi L, Monsel A, et al. Mesenchymal stem cell microvesicles attenuate acute lung injury in mice partly mediated by Ang⁃1 mRNA［J］. Stem Cells, 2017,35（7）:1849⁃1859. doi: 10.1002/stem.2619.
［10］	Katsuda T, Ochiya T. Molecular signatures of mesenchymal stem cell⁃derived extracellular vesicle⁃mediated tissue repair［J］. Stem Cell Res Ther, 2015,6:212. doi: 10.1186/s13287⁃015⁃0214⁃y.
［11］	Ge L, Xun C, Li W, et al. Extracellular vesicles derived from hypoxia⁃preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR⁃612［J］. J Nanobiotechnology, 2021,19（1）:380. doi: 10.1186/s12951⁃021⁃01126⁃6.
［12］	Tavasolian F, Hosseini AZ, Soudi S, et al. miRNA⁃146a improves immunomodulatory effects of MSC⁃derived exosomes in rheumatoid arthritis［J］. Curr Gene Ther, 2020,20（4）:297⁃312. doi: 10.2174/1566523220666200916120708.
［13］	Zhang Y, Pan Y, Liu Y, et al. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor⁃β receptor inhibition［J］. Stem Cell Res Ther, 2021,12（1）:434. doi: 10.1186/s13287⁃021⁃02517⁃0.
［14］	Gezer U, Özgür E, Cetinkaya M, et al. Long non⁃coding RNAs with low expression levels in cells are enriched in secreted exosomes［J］. Cell Biol Int, 2014,38（9）:1076⁃1079. doi: 10. 1002/cbin.10301.
［15］	Li B, Luan S, Chen J, et al. The MSC⁃derived exosomal lncRNA H19 promotes wound healing in diabetic foot ulcers by upregulating PTEN via microRNA⁃152⁃3p［J］. Mol Ther Nucleic Acids, 2020,19:814⁃826. doi: 10.1016/j.omtn.2019.11.034.
［16］	Dou R, Zhang X, Xu X, et al. Mesenchymal stem cell exosomal tsRNA⁃21109 alleviate systemic lupus erythematosus by inhibiting macrophage M1 polarization［J］. Mol Immunol, 2021,139:106⁃114. doi: 10.1016/j.molimm.2021.08.015.
［17］	Lai RC, Tan SS, Teh BJ, et al. Proteolytic potential of the MSC exosome proteome: implications for an exosome⁃mediated delivery of therapeutic proteasome［J］. Int J Proteomics, 2012,2012:971907. doi: 10.1155/2012/971907.
［18］	Zhang B, Wang M, Gong A, et al. HucMSC⁃exosome mediated⁃Wnt4 signaling is required for cutaneous wound healing［J］. Stem Cells, 2015,33（7）:2158⁃2168. doi: 10.1002/stem.1771.
［19］	Zhang B, Shi Y, Gong A, et al. HucMSC exosome⁃delivered 14⁃3⁃3ζ orchestrates self⁃control of the Wnt response via modulation of YAP during cutaneous regeneration［J］. Stem Cells, 2016,34（10）:2485⁃2500. doi: 10.1002/stem.2432.
［20］	Shabbir A, Cox A, Rodriguez⁃Menocal L, et al. Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro［J］. Stem Cells Dev, 2015,24（14）:1635⁃1647. doi: 10.1089/scd. 2014.0316.
［21］	Liu H, Liang Z, Wang F, et al. Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage⁃ dependent mechanism［J］. JCI Insight, 2019,4（24）:e131273. doi: 10.1172/jci.insight.131273.
［22］	Yang S, Liang X, Song J, et al. A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG⁃6［J］. Stem Cell Res Ther, 2021,12（1）:315. doi: 10.1186/s13287⁃021⁃02404⁃8.
［23］	Ha DH, Kim HK, Lee J, et al. Mesenchymal stem/stromal cell⁃derived exosomes for immunomodulatory therapeutics and skin regeneration［J］. Cells, 2020,9（5）:1157. doi: 10.3390/cells9051157.
［24］	Silachev DN, Goryunov KV, Shpilyuk MA, et al. Effect of MSCs and MSC⁃derived extracellular vesicles on human blood coagulation［J］. Cells, 2019,8（3）:258. doi: 10.3390/cells803 0258.
［25］	夏娜, 高超, 刘璇, 等. 脐带间充质干细胞外泌体对急性皮肤创面愈合的初步研究［J］.中华皮肤科杂志, 2022,55（5）:382⁃388. doi: 10.35541/cjd.20210831.
［26］	Zhao W, Zhang R, Zang C, et al. Exosome derived from mesenchymal stem cells alleviates pathological scars by inhibiting the proliferation, migration and protein expression of fibroblasts via delivering miR⁃138⁃5p to target SIRT1［J］. Int J Nanomedicine, 2022,17:4023⁃4038. doi: 10.2147/IJN.S377317.
［27］	Yang C, Sun J, Tian Y, et al. Immunomodulatory effect of MSCs and MSCs⁃derived extracellular vesicles in systemic lupus erythematosus［J］. Front Immunol, 2021,12:714832. doi: 10. 3389/fimmu.2021.714832.
［28］	Bolandi Z, Mokhberian N, Eftekhary M, et al. Adipose derived mesenchymal stem cell exosomes loaded with miR⁃10a promote the differentiation of Th17 and Treg from naive CD4（+） T cell［J］. Life Sci, 2020,259:118218. doi: 10.1016/j.lfs.2020.118218.
［29］	Adamo A, Brandi J, Caligola S, et al. Extracellular vesicles mediate mesenchymal stromal cell⁃dependent regulation of B cell PI3K⁃AKT signaling pathway and actin cytoskeleton［J］. Front Immunol, 2019,10:446. doi: 10.3389/fimmu.2019.00446.
［30］	Shahir M, Mahmoud Hashemi S, Asadirad A, et al. Effect of mesenchymal stem cell⁃derived exosomes on the induction of mouse tolerogenic dendritic cells［J］. J Cell Physiol, 2020,235（10）:7043⁃7055. doi: 10.1002/jcp.29601.
［31］	Dong B, Wang C, Zhang J, et al. Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid⁃resistant asthma by reshaping macrophage polarization［J］. Stem Cell Res Ther, 2021,12（1）:204. doi: 10. 1186/s13287⁃021⁃02244⁃6.
［32］	Ye Z, Liang Y, Lin B, et al. Gingiva⁃derived mesenchymal stem cells attenuate imiquimod⁃ （IMQ⁃） induced murine psoriasis⁃like skin inflammation［J］. Stem Cells Int, 2022,2022:6544514. doi: 10.1155/2022/6544514.
［33］	韩齐心, 牛旭平, 刘佳, 等. 间充质干细胞及其外泌体与Th17/Treg对银屑病发病机制的研究进展［J］.中华皮肤科杂志, 2020,53（2）:151⁃154. doi: 10.35541/cjd.20190012.
［34］	Ghoreschi K, Balato A, Enerbäck C, et al. Therapeutics targeting the IL⁃23 and IL⁃17 pathway in psoriasis［J］. Lancet, 2021,397（10275）:754⁃766. doi: 10.1016/S0140⁃6736（21）00184⁃7.
［35］	Xu F, Fei Z, Dai H, et al. Mesenchymal stem cell⁃derived extracellular vesicles with high PD⁃L1 Expression for Autoimmune Diseases Treatment［J］. Adv Mater, 2022,34（1）:e2106265. doi: 10.1002/adma.202106265.
［36］	Shin KO, Ha DH, Kim JO, et al. Exosomes from human adipose tissue⁃derived mesenchymal stem cells promote epidermal barrier repair by inducing de novo synthesis of ceramides in atopic dermatitis［J］. Cells, 2020,9（3）:680. doi: 10.3390/cells 9030680.
［37］	Deng M, Yu TZ, Li D, et al. Human umbilical cord mesenchymal stem cell⁃derived and dermal fibroblast⁃derived extracellular vesicles protect dermal fibroblasts from ultraviolet radiation⁃induced photoaging in vitro［J］. Photochem Photobiol Sci, 2020,19（3）:406⁃414. doi: 10.1039/c9pp00421a.
［38］	Zhang K, Yu L, Li FR, et al. Topical application of exosomes derived from human umbilical cord mesenchymal stem cells in combination with sponge spicules for treatment of photoaging［J］. Int J Nanomedicine, 2020,15:2859⁃2872. doi: 10.2147/IJN.S249751.
［39］	Ding Q, Sun R, Wang P, et al. Protective effects of human induced pluripotent stem cell⁃derived exosomes on high glucose⁃induced injury in human endothelial cells［J］. Exp Ther Med, 2018,15（6）:4791⁃4797. doi: 10.3892/etm.2018.6059.

[1]	Ye Hui, Deng Shilin, Liang Jingyao, Zhang Xibao. Correlations between the control of atopic dermatitis recurrence and tissue-resident memory T cells [J]. Chinese Journal of Dermatology, 2025, 0(3): 20240192-e20240192.
[2]	Li Xiangqian, Zhang Jianzhong, Zhou Cheng. Advances in the clinical research on systemic small-molecule drugs and biologics for the treatment of alopecia areata [J]. Chinese Journal of Dermatology, 2025, 0(3): 20240247-e20240247.
[3]	Wang Wenqiu, Li Chengxin, Wang Rui. Biologics for the treatment of psoriasis relapse: current status [J]. Chinese Journal of Dermatology, 2025, 0(3): 20230301-e20230301.
[4]	Li Meirong, Tang Xuhua, Wu Rong, Liu Wentao, Feng Peiying. Four cases of skin infections caused by rare Neoscytalidium dimidiatum in China [J]. Chinese Journal of Dermatology, 2025, 0(2): 20230579-e20230579.
[5]	Committee on Skin Disease and Cosmetic Dermatology, China Association of Medical Equipment. Expert consensus on the treatment of dermatoses with targeted drugs （2025 version） [J]. Chinese Journal of Dermatology, 2025, 58(2): 99-125.
[6]	Chen Jiaqi, Zhang Jin, Tang Jun. Relationships between coronavirus disease 2019 and psoriasis [J]. Chinese Journal of Dermatology, 2025, 58(1): 84-88.
[7]	Chinese Association of Rehabilitation Dermatology, Working Group on Geriatric Dermatology, Combination of Traditional and Western Medicine Dermatology. Expert consensus on the diagnosis, treatment, and rehabilitation of pruritus in the elderly （2025 edition） [J]. Chinese Journal of Dermatology, 2025, 58(1): 1-8.
[8]	Chinese Association of Rehabilitation Dermatology, Chinese Association of Photodynamic Therapy and Rehabilitation, Photodynamic Therapy Cooperation Center, Chinese Society of Dermatology . Expert consensus on clinical application of aminolevulinic acid photodynamic therapy in non-melanoma skin cancers （2025 edition） [J]. Chinese Journal of Dermatology, 2025, 58(1): 9-19.
[9]	Liao Caihe, Wang Peiru, Wu Mingshun, Sun Xiaofei, Zhang Guolong, Wang Xiuli. Efficacy and safety of combination therapy with aminolevulinic acid photodynamic therapy in the treatment of facial basal cell carcinoma in the elderly: a retrospective analysis [J]. Chinese Journal of Dermatology, 2025, 58(1): 34-39.
[10]	Jin Lan, Qiu Yun, Wang Weijia, Kang Xiaojing, Ding Yuan. Clinical efficacy and safety of biological agents in the treatment of moderate-to-severe psoriasis in 124 elderly patients: a retrospective analysis [J]. Chinese Journal of Dermatology, 2025, 58(1): 47-52.
[11]	Wang Bo, Zheng Jie. Considerations in the treatment of elderly patients with psoriasis and atopic dermatitis using biologics and small-molecule drugs [J]. Chinese Journal of Dermatology, 2025, 58(1): 72-75.
[12]	Wang Ruixia, Qu Yanlei, Ai Wenjin, Yan Lin, Qu Caijie, Shi Tongxin. A case of nonbullous neutrophilic lupus erythematosus [J]. Chinese Journal of Dermatology, 2024, 57(9): 832-834.
[13]	Xiang Xi, Zhang Lingyan, Zhong Lin, Gao Yi, Qiu Li. Multimodal ultrasound manifestations of port-wine stains and their application in efficacy assessment of photodynamic therapy [J]. Chinese Journal of Dermatology, 2024, 57(9): 801-806.
[14]	Qiao Jiaxi, Xia Ping, Chen Liuqing. Analysis of dermoscopic and reflectance confocal microscopic features of psoriatic lesions before and after treatment with secukinumab [J]. Chinese Journal of Dermatology, 2024, 57(9): 825-829.
[15]	Luo Li, Zhang Bona, Wu Wei, Tang Wenjing, Li Yuehua, Liu Xiaoli, Ma Yanan, Li Cuicui, Qi Mengyan, Sun Ni, Shi Qiong. Efficacy and safety of 308-nm excimer laser and 308-nm excimer lamp in the treatment of 194 children with vitiligo: a retrospective study [J]. Chinese Journal of Dermatology, 2024, 57(8): 721-727.

Role of mesenchymal stem cell-derived exosomes in skin diseases

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［39］

Related Articles 15

Metrics

Comments

Recommended 10