抗病毒免疫在银屑病中的研究

doi:10.35541/cjd.20210254

Abstract

Abstract: 【Abstract】 This review summarizes reports on viral infection?induced psoriasis, as well as research advances in mechanisms underlying antiviral innate immunity and acquired immunity in psoriasis, and discusses the important role of viral infection in the occurrence and development of psoriasis, providing new ideas for effective prevention and treatment of psoriasis.

Key words: Psoriasis, Viruses, Immunity, Interferons, Antiviral immunity

Huang Yanzhou, Zheng Min. Antiviral immunity in psoriasis[J]. Chinese Journal of Dermatology, 2023, 56(12): 1177-1180.doi:10.35541/cjd.20210254

References ［43］

［1］	Griffiths CEM, Armstrong AW, Gudjonsson JE, et al. Psoriasis［J］. Lancet, 2021, 397（10281）:1301⁃1315. doi: 10.1016/S0140⁃6736（20）32549⁃6.
［2］	Streicher F, Jouvenet N. Stimulation of innate immunity by host and viral RNAs［J］. Trends Immunol, 2019,40（12）:1134⁃1148. doi: 10.1016/j.it.2019.10.009.
［3］	Handfield C, Kwock J, MacLeod AS. Innate antiviral immunity in the skin［J］. Trends Immunol, 2018,39（4）:328⁃340. doi: 10. 1016/j.it.2018.02.003.
［4］	Strumillo ST, Kartavykh D, de Carvalho FF Jr, et al. Host⁃virus interaction and viral evasion［J］. Cell Biol Int, 2021,45（6）:1124⁃1147. doi: 10.1002/cbin.11565.
［5］	Yiu Z, Parisi R, Lunt M, et al. Risk of hospitalization and death due to infection in people with psoriasis: a population⁃based cohort study using the Clinical Practice Research Datalink［J］. Br J Dermatol, 2021,184（1）:78⁃86. doi: 10.1111/bjd.19052.
［6］	Yoneda K, Matsuoka⁃Shirahige Y, Demitsu T, et al. Pustular psoriasis precipitated by cytomegalovirus infection［J］. Br J Dermatol, 2012,167（5）:1186⁃1189. doi: 10.1111/j.1365⁃2133. 2012.11044.x.
［7］	Loh E, Fung MA, Maverakis E. Acute guttate psoriasis in a 15⁃year⁃old girl with Epstein⁃Barr virus infection［J］. Arch Dermatol, 2012,148（5）:658⁃659. doi: 10.1001/archdermatol.2011. 3517.
［8］	Jiyad Z, Moriarty B, Creamer D, et al. Generalized pustular psoriasis associated with Epstein⁃Barr virus［J］. Clin Exp Dermatol, 2015,40（2）:146⁃148. doi: 10.1111/ced.12493.
［9］	Chen ML, Kao WM, Huang JY, et al. Human papillomavirus infection associated with increased risk of new⁃onset psoriasis: a nationwide population⁃based cohort study［J］. Int J Epidemiol, 2020,49（3）:786⁃797. doi: 10.1093/ije/dyaa027.
［10］	李远宏, 陈光, 张理涛, 等. 银屑病患者皮损及鳞屑中人乳头瘤病毒的检测［J］. 中华皮肤科杂志, 2008,41（10）:695⁃696. doi: 10.3321/j.issn:0412⁃4030.2008.10.020.
［11］	王官清, 张理涛, 徐宏慧, 等. 寻常型银屑病与单纯疱疹病毒1型相关性的研究［J］. 中华皮肤科杂志, 2002,35（2）:102⁃104. doi: 10.3760/j.issn:0412⁃4030.2002.02.007.
［12］	Queirós N, Torres T. HIV⁃associated psoriasis［J］. Actas Dermosifiliogr （Engl Ed）, 2018,109（4）:303⁃311. doi: 10.1016/j.ad.2017.09.014.
［13］	Li YY, Dong RJ, Cao LJ, et al. Case of coincident severe acne and psoriasis in AIDS patient successfully treated with antiretroviral therapy［J］. J Dermatol, 2019,46（5）:431⁃435. doi: 10.1111/1346⁃8138.14823.
［14］	Bowles AA, Smirnov B. Erythrodermic psoriasis and HIV infection［J］. N Engl J Med, 2019,380（1）:80. doi: 10.1056/NEJMicm1810005.
［15］	Kuwatsuka S, Koike Y, Asai M, et al. Numerous plasmacytoid dendritic cell infiltration in HIV⁃associated psoriasis relieved only with antiretroviral therapy［J］. J Dermatol, 2018,45（9）:1126⁃1129. doi: 10.1111/1346⁃8138.14525.
［16］	Seetharam KA, Sridevi K. Chikungunya infection: a new trigger for psoriasis［J］. J Dermatol, 2011,38（10）:1033⁃1034. doi: 10. 1111/j.1346⁃8138.2011.01200.x.
［17］	Sbidian E, Madrange M, Viguier M, et al. Respiratory virus infection triggers acute psoriasis flares across different clinical subtypes and genetic backgrounds［J］. Br J Dermatol, 2019,181（6）:1304⁃1306. doi: 10.1111/bjd.18203.
［18］	Shahidi Dadras M, Diab R, Ahadi M, et al. Generalized pustular psoriasis following COVID⁃19［J］. Dermatol Ther, 2021,34（1）:e14595. doi: 10.1111/dth.14595.
［19］	Novelli L, Motta F, Ceribelli A, et al. A case of psoriatic arthritis triggered by SARS⁃CoV⁃2 infection［J］. Rheumatology （Oxford）, 2021,60（1）:e21⁃e23. doi: 10.1093/rheumatology/keaa691.
［20］	Gananandan K, Sacks B, Ewing I. Guttate psoriasis secondary to COVID⁃19［J］. BMJ Case Rep, 2020,13（8）:e237367. doi: 10.1136/bcr⁃2020⁃237367.
［21］	Ferreira CR, Crow YJ, Gahl WA, et al. DDX58 and classic Singleton⁃Merten syndrome［J］. J Clin Immunol, 2019,39（1）:75⁃80. doi: 10.1007/s10875⁃018⁃0572⁃1.
［22］	Prasov L, Bohnsack BL, El Husny AS, et al. DDX58（RIG⁃I）⁃related disease is associated with tissue⁃specific interferon pathway activation［J］. J Med Genet, 2022,59（3）:294⁃304. doi: 10.1136/jmedgenet⁃2020⁃107447.
［23］	Abu Tayeh A, Funabiki M, Shimizu S, et al. Psoriasis⁃like skin disorder in transgenic mice expressing a RIG⁃I Singleton⁃Merten syndrome variant［J］. Int Immunol, 2021,33（4）:211⁃224. doi: 10.1093/intimm/dxaa071.
［24］	Yao Y, Richman L, Morehouse C, et al. Type I interferon: potential therapeutic target for psoriasis?［J］. PLoS One, 2008,3（7）:e2737. doi: 10.1371/journal.pone.0002737.
［25］	Wang X, Liu X, Liu N, et al. Prediction of crucial epigenetically⁃associated, differentially expressed genes by integrated bioinformatics analysis and the identification of S100A9 as a novel biomarker in psoriasis［J］. Int J Mol Med, 2020,45（1）:93⁃102. doi: 10.3892/ijmm.2019.4392.
［26］	Gao Y, Yao X, Zhai Y, et al. Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregula⁃tory axis conducted by skin resident cells［J］. Cell Death Dis, 2021,12（5）:450. doi: 10.1038/s41419⁃021⁃03724⁃6.
［27］	Li Y, Song Y, Zhu L, et al. Interferon kappa is up⁃regulated in psoriasis and it up⁃regulates psoriasis⁃associated cytokines in vivo［J］. Clin Cosmet Investig Dermatol, 2019,12:865⁃873. doi: 10.2147/CCID.S218243.
［28］	Sevimoglu T, Turanli B, Bereketoglu C, et al. Systems biomarkers in psoriasis: integrative evaluation of computational and experimental data at transcript and protein levels［J］. Gene, 2018,647:157⁃163. doi: 10.1016/j.gene.2018.01.033.
［29］	Zhou Y, Wang P, Yan BX, et al. Quantitative proteomic profile of psoriatic epidermis identifies OAS2 as a novel biomarker for disease activity［J］. Front Immunol, 2020,11:1432. doi: 10. 3389/fimmu.2020.01432.
［30］	Lande R, Gregorio J, Facchinetti V, et al. Plasmacytoid dendritic cells sense self⁃DNA coupled with antimicrobial peptide［J］. Nature, 2007,449（7162）:564⁃569. doi: 10.1038/nature06116.
［31］	Pahar B, Madonna S, Das A, et al. Immunomodulatory role of the antimicrobial LL⁃37 peptide in autoimmune diseases and viral infections［J］. Vaccines （Basel）, 2020,8（3）:517. doi: 10.3390/vaccines8030517.
［32］	Ganguly D, Chamilos G, Lande R, et al. Self⁃RNA⁃antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8［J］. J Exp Med, 2009,206（9）:1983⁃1994. doi: 10. 1084/jem.20090480.
［33］	Zhang LJ, Sen GL, Ward NL, et al. Antimicrobial peptide LL37 and MAVS signaling drive interferon⁃β production by epidermal keratinocytes during skin injury［J］. Immunity, 2016,45（1）:119⁃130. doi: 10.1016/j.immuni.2016.06.021.
［34］	Lande R, Botti E, Jandus C, et al. The antimicrobial peptide LL37 is a T⁃cell autoantigen in psoriasis［J］. Nat Commun, 2014,5:5621. doi: 10.1038/ncomms6621.
［35］	Zhang LJ. Type1 interferons potential initiating factors linking skin wounds with psoriasis pathogenesis［J］. Front Immunol, 2019,10:1440. doi: 10.3389/fimmu.2019.01440.
［36］	Afshar M, Martinez AD, Gallo RL, et al. Induction and exacerbation of psoriasis with Interferon⁃alpha therapy for hepatitis C: a review and analysis of 36 cases［J］. J Eur Acad Dermatol Venereol, 2013,27（6）:771⁃778. doi: 10.1111/j.1468⁃3083.2012.04582.x.
［37］	Gui J, Gober M, Yang X, et al. Therapeutic elimination of the type 1 interferon receptor for treating psoriatic skin inflammation［J］. J Invest Dermatol, 2016,136（10）:1990⁃2002. doi: 10.1016/j.jid.2016.06.608.
［38］	Fu LX, Chen T, Guo ZP, et al. Enhanced serum interferon⁃lambda 1 interleukin⁃29 levels in patients with psoriasis vulgaris［J］. An Bras Dermatol, 2021,96（4）:416⁃421. doi: 10.1016/j.abd. 2020.11.007.
［39］	Wolk K, Witte K, Witte E, et al. IL⁃29 is produced by T（H）17 cells and mediates the cutaneous antiviral competence in psoriasis［J］. Sci Transl Med, 2013,5（204）:204ra129. doi: 10. 1126/scitranslmed.3006245.
［40］	Zhu H, Lou F, Yin Q, et al. RIG⁃I antiviral signaling drives interleukin⁃23 production and psoriasis⁃like skin disease［J］. EMBO Mol Med, 2017,9（5）:589⁃604. doi: 10.15252/emmm.2016 07027.
［41］	Bijlmakers MJ, Kanneganti SK, Barker JN, et al. Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double⁃stranded RNA in disease pathogenesis［J］. Hum Mol Genet, 2011,20（16）:3129⁃3137. doi: 10.1093/hmg/ddr215.
［42］	Lima⁃Junior DS, Krishnamurthy SR, Bouladoux N, et al. Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota［J］. Cell, 2021,184（14）:3794⁃3811.e19. doi: 10.1016/j.cell.2021.05.020.
［43］	Ariza ME, Williams MV. A human endogenous retrovirus K dUTPase triggers a TH1, TH17 cytokine response: does it have a role in psoriasis?［J］. J Invest Dermatol, 2011,131（12）:2419⁃2427. doi: 10.1038/jid.2011.217.

[1]	Chen Xingyu, Yao Xu. Role of neutrophils in inflammatory dermatoses [J]. Chinese Journal of Dermatology, 2024, 0(3): 20220865-e20220865.
[2]	Wu Yubing, Wang Xiaoyu, An Binyi, Wu Yingying, Sang Hong, Kong Qingtao, . Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes signaling pathway in the occurrence of psoriasis [J]. Chinese Journal of Dermatology, 2024, 0(3): 20230394-e20230394.
[3]	Zhu Tingting, Zhang Xuejun. Apremilast in the treatment of plaque psoriasis [J]. Chinese Journal of Dermatology, 2024, 0(3): 20230448-e20230448.
[4]	Hao Dan, Wang Yiyi, Xiao Yue, Yan Wei, Li Wei. Systemic treatment options for psoriasis in special areas [J]. Chinese Journal of Dermatology, 2024, 0(3): 20230190-e20230190.
[5]	Wang Shiqi, Wang Aiping, Li Hang, Li Ruoyu. Comparison of dermoscopic features of toenail psoriasis and fingernail psoriasis [J]. Chinese Journal of Dermatology, 2024, 57(2): 161-165.
[6]	Wang Haoyang, Wang Yidan, Lu Yan . Role of neurogenic inflammatory factors in the pathogenesis of vitiligo [J]. Chinese Journal of Dermatology, 2024, 57(1): 78-81.
[7]	Liu Xiaoyang, Zhao Yan, Cai Lin, Zhang Jianzhong. Atopic dermatitis-like lesions appearing after interleukin-17 antagonist therapy in 4 cases of psoriasis: case analysis and literature review [J]. Chinese Journal of Dermatology, 2023, 56(9): 845-848.
[8]	Fu Dandan, Li Jialin, Fu Xiuyu, Zhang Xinyu, Hu Hua, Song Xiangfeng, Tian Zhongwei. S100A10 protein expression in psoriatic lesions and its effect on psoriasis-like skin inflammation in mouse models [J]. Chinese Journal of Dermatology, 2023, 56(9): 839-844.
[9]	Chen Xiaomin, Zhang Jingzhan, Ding Yuan, Kang Xiaojing. Metformin in the treatment of psoriasis [J]. Chinese Journal of Dermatology, 2023, 56(8): 799-802.
[10]	Jiang Xiaoyan, Gao Min, Zhang Xiaoyan, Liu Ningyuan. Interleukin-17 and interleukin-23 inhibitors in the treatment of pustular psoriasis [J]. Chinese Journal of Dermatology, 2023, 56(7): 689-692.
[11]	Shan Ying, Chang Xiaotong, Zuo Yagang. Epitope spreading in autoimmune bullous diseases [J]. Chinese Journal of Dermatology, 2023, 56(7): 702-705.
[12]	Liu Weizhao, Duan Zhimin, Wang Jianing, Li Min, Chen Xu, . Counteractive effect of mouse dermal fibroblasts during their adipogenic differentiation against Staphylococcus aureus infection and its mechanisms [J]. Chinese Journal of Dermatology, 2023, 56(7): 630-635.
[13]	Tang Zhiming, Jing Mengqing, Lu Lu, Shan Xiao, Zhang Cuixia, Zhang Xiaoyu, Meng Sa. Effect of Xidi Liangxue recipe on the proliferation and apoptosis of HaCaT cells through the lncRNA NEAT1/miR-485-5p/STAT3 regulatory network [J]. Chinese Journal of Dermatology, 2023, 56(7): 642-650.
[14]	Committee on Psoriasis, Chinese Society of Dermatology. Guideline for the diagnosis and treatment of psoriasis in China （2023 edition） [J]. Chinese Journal of Dermatology, 2023, 56(7): 573-625.
[15]	China Dermatologist Association, Chinese Society of Dermatology, Xijing Hospital, Air Force Medical University, Chinese Dietary Guideline for Psoriasis Patients Task Force. Dietary guideline for patients with psoriasis in China （2023） [J]. Chinese Journal of Dermatology, 2023, 56(5): 389-401.

Antiviral immunity in psoriasis

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［43］

Related Articles 15

Metrics

Comments

Recommended 10