Abstract: Zheng Yuechen, Zeng Jingsi, Lian Xin, Zhang Guiying, Mao Yehong. Department of Dermatovenereology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Corresponding author: Zeng Jingsi, Email: wuhanzjs@aliyun.com 【Abstract】 Objective To report two cases of Candida parapsilosis-caused candidiasis characterized by verrucous nodules and masses, and to assess their clinical features, diagnosis and treatment. Methods A medical history including medication history and therapeutic response was carefully collected from two male patients. Physical examination was carried out with a focus on skin lesions. Diagnosis was made according to medical history as well as physical, mycological and histopathological examination findings. Antifungal agents were given at a high enough dose in time. After lesions improved, the doses of antifungal agents were tapered gradually, and drugs were withdrawn until patients completely healed. Compound preparations containing both antifungal agents and glucocorticoids were also topically applied in the early period of treatment. Results Both patients were diagnosed as Candida parapsilosis-caused candidiasis characterized by verrucous nodules and masses, and cured after 100-day supporting treatment and antifungal treatment with oral itraconazole, etc. Conclusions Candida parapsilosis-caused candidiasis should be managed with combination therapy mainly including antifungal agents. To achieve a satisfying efficacy, antifungal agents should be given early at a high enough dose for a long enough period.

Key words: Canaida parapsilosis, Verrucous nodule, Skin manifestations