Abstract: Meng Liya*, Wang Yifei, Zhang Chunmin. *Department of Dermatology, Second Hospital of Shandong University, Jinan 250033, China Corresponding author: Meng Liya, Email: mly0706@sina.com 【Abstract】 Objective To evaluate the efficacy and safety of fractionated CO2 laser combined with 308-nm excimer laser for the treatment of stable vitiligo. Methods Forty-nine patients with 109 lesions of stable vitiligo were enrolled in this clinical trial. Each of these lesions was equally divided into 2 parts along the longest diameter, which were then assigned into the treatment group and control group respectively. The treatment group were treated with fractionated CO2 laser radiation for 15 － 20 minutes once every two weeks combined with 308-nm excimer laser radiation twice weekly. The control group were only treated with 308-nm excimer laser radiation twice weekly. Efficacy was evaluated on day 3 after 12 consecutive weeks of treatment. Results After the treatment, the total response rate in the treatment group and control group was 92.7% （101/109） and 77.1% （84/109） respectively. The marked response rate in the treatment group and control group was 85.4% （35/41） and 65.8% （27/41） respectively for lesions on the face and neck （χ2 = 4.23, P < 0.05）, 70.6% （24/34） and 41.2% （14/34） respectively for lesions on the trunk （χ2 = 7.27, P < 0.01）, 64.0% （16/25） and 36.0% （9/25） respectively for lesions on the extremities （χ2 = 3.92, P < 0.05）, 5/9 and 1/9 respectively for lesions on the dorsal hands （χ2 = 4.00, P < 0.05）. The number of sessions of 308-nm excimer laser therapy required for the marked response of vitiligo in the treatment group and control group was 7.24 ± 1.23 and 10.81 ± 2.01 respectively for lesions on the face and neck （t = 9.70, P < 0.05）, 15.10 ± 2.47 and 18.95 ± 3.45 respectively for lesions on the trunk （t = 5.29, P < 0.05）, 17.37 ± 3.84 and 21.06 ± 4.23 respectively for lesions on the extremities （t = 3.23, P < 0.05）. No severe adverse reactions were observed in any of the patients during the treatment. Conclusion Fractionated CO2 laser combined with 308-nm excimer laser is effective and safe in treating stable vitiligo.

Key words: Vitiligo, Fractional laser, Efficacy