Abstract:

Abstracr Objective To explore the relationship between cancer stem cell and adult stem cell. Method Immunohistochemistry staining was used to detect expression of stem cell related marker p63，CD44, CD200 in squamous cell carcinoma(SCC). Results: Similar expression pattern of p63，CD44 was found in SCC, which showed that most positive cells located in out layer of the tumor and decreased near center of well differentiated SCC. However, positive cells were scattered in poor differentiated SCC. CD200 were not seen in SCC but in lymphocyte and endothelia of vascular adjacent tumor. Conclusion: we proposed cancer stem cell derived from dysfunction of normal adult stem cell could locate in SCC, while CSC has different genes expression compared with adult stem cell.

Key words: Stem cell factor