Chinese Journal of Dermatology ›› 2010, Vol. 43 ›› Issue (12): 892-894.

• Review • Previous Articles    

microRNA-mediated regulation in skin diseases

  

  • Received:2010-04-26 Revised:2010-06-11 Online:2010-12-15 Published:2010-12-13

Abstract:

Abstract: MicroRNAs (miRNAs) are very small endogenous RNA molecules about 19-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have been shown to regulate several developmental and physiological processes,including cell proliferation、 differentiation、apoptosis and the immune response. Recent findings report their potentials in globally regulating the pathogenesis of many skin diseases. Here, we reviewed the roles of miRNAs in a series of skin diseases including skin tumor、psoriasis、systemic lupus erythematosus、scleroderma 、Male Pattern Baldness and wound healing,which provide great potential and new trends for the diagnosis and therapy of these skin diseases.

Key words: MicroRNAs