Chinese Journal of Dermatology ›› 2010, Vol. 43 ›› Issue (11): 805-806.
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【Abstract】 Objective To explore the pathogenesis of genital herpes from the view of innate immune response through detecting the expressions of TLR9,IL-13and IIL-15.Methods Fifty-six cases of genital herpes and 27 healthy controls were collected.Flow Cytometer method was used to detect the expression of TLR9 in the peripheral blood;ELISA assay was used to detect the expression of IL-13 and IL-15 in the serum.Results The expression of TLR9,IL-13 in the genital herpes group were higher than which of the controls. There was significance difference between these two groups.But,serum IL-15 levels was no difference between these two groups.Conclusions TLR9 participated in the immunologic process to the herpes simplex virus and induced Th2 immune response.
Key words: 【Key words】 Genital herpes, Toll-like receptor, Interleukin-13, Interleukin-15
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