Abstract: Objective To evaluate the possible association between depression and cellular immunologic status in patients with condyloma acuminatum (CA). Method Depression was assessed with the Self-rating Depression Scale (SDS) and the activity of natural killer (NK) cells, the interleukin-2 (IL-2) produced by peripheral blood mononuclear cells (PBMC) were measured in 60 patients with CA. Results The SDS scores in patients with CA were significantly higher than those in the controls (P<0.01), and 43.33% of the patients were affected by depression. The mean scores of depression among patients with long duration of treatment (> 3 months) were significantly higher than those in patients with short duration (≤3 months) (P<0.05). In patients affected by depression, the level of IL-2 produced by PBMC and the activity of NK cells were significantly decreased (P<0.05 or P<0.01). Conclusion Patients with CA are usually affected by depression and the cellular immunologic status is usually impaired among the patients with depression.

Key words: Condylomata acuminata, Depressive disorder, Interleukin-2, Killer cells, natural