Abstract: Objective To investigate the effects of compound bifonazole solution for the treatment of superficial mycosis.Methods The study groups were treated with compound bifonazole solution and the control group with clotrimazole solution in a double-blind controlled clinical trial.The solutions were applied to skin lesions once a day.The course of treatment was two weeks for tinea corporis and tinea cruris and four weeks for tinea manus and tinea pedis.The patients were followed up weekly for two weeks after cessation of treatment and evaluated with regard to erythema,papule,blister,scale,keratinization and pruritus.Mycologic examinations were performed before,during and right after treatment and two weeks after treatment.Results A total of 434 patients participated into the study.The clinical cure rates of study group were 82.25% in tinea corporis and tinea cruris,and68.75%tinea manus and tinea pedis,with a total response rates of 95.85% and 92.5% in tinea corporis and tinea cruris,and 92.5% in tinea manus and tinea pedis,respectively.The clinical cure rates of control group were 58.6% in tinea corporis and tinea cruris,and 44.7% in tinea manus and tinea pedis,with a total response rates of 83.0% and 87.2% in tinea corporis and tinea cruris,and in tinea manus and tinea pedis,respectively.The MICs to350clinical isolates of pathogenic fungi were 1.6~2.5mg/L for compound bifonazole solution,and 3.125~25mg/L for clotrimazole solution.Conclusions Compound bifonazole solution is a high-effective,broad-spectrum antifungal agent.It is keratolytic,well permeable and safe for relatively long term application.

Key words: Tinea, Clotrimazole, Bifonazole, Administration,cutaneous