Chinese Journal of Dermatology ›› 2003, Vol. 36 ›› Issue (6): 342-344.

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Treatment of Keloid with Centella Tripterpenes After Surgical Excision and X-Ray Irradiation

ZHAO Liang, FANG Fang, WANG Yan, WU Xin-feng, WANG Qiang, CHEN Xiao-dong, GONG Xiang-dong, ZHANG Guo-cheng   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
  • Received:2002-03-07 Online:2003-06-15 Published:2003-06-15

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Abstract: Objective To validate the therapeutic effect of Centella Triterpenes after surgical excision and X-ray irradiation.Methods Surgical excision was performed on one hundred and six patients with keloid,after operation superficial X-ray irradiation was given to the patients.Then,they were divided into three groups:36 cases in group A treated with higher dose of Centella Triterpenes;39 cases in group B treated with lower dose of Centella Triterpenes;31 cases took placebo as controls.All patients were followed up for 12 months after treatment.Results All patients were healed completely after operation.The effective rate was significantly higher in Centella Triterpenes groups than that in the control group(P<0.01).No significant difference was found between the effective rates of group A and group B.Conclusions Combination therapy with centella Triterpenes surgical operation and superficial X-ray irradiation is effective in treating keloid with mild adverse reactions.

Key words: Keloid, Centella Triterpenes Tablets