Abstract: Objective To investigate the antimicrobial susceptibility of spectinomycin、minocycline、azithromycin and sparfloxacin to mycoplasma(Uu and Mh)and therapeutic effect of spectinomycin to my-coplasma infection in genitourinary tract.Methods ①The susceptibility test:each of the 4 drugs was divided into two concentrations.One was at 1 μg/mL(sensitive concentration)and the other was at 4 μg/mL(resistant concentration).If mycoplasma does not grow in both concentrations,it means the drug tested is sensitive.If it grows in both concentrations,the drug tested is resistant.If mycoplasma grows in lower concentration and does not in higher concentration,it means moderate sensitive.②Treatment regimen:Spectinomycin was injected,2g/d IM,for 7-10 days as a course of treatmeant.Patients were followed-up 7 days later and 2~4 weeks after treatment.Results ①Among 1658 specimens,519 were found Uu positive,and 61 Mh positive.The resistance rates of Uu to 4 different drugs were:7.7% for minocycline,21.4% for sparfloxacin,13.9% for azit hromycin and 7.3% for spectinomycin.Whereas,those of Mh were:18.0%,45.9%,54.1%,and 29.5% respectively.②The clinical effect of spectinomycin was:out of 43 treated patients,37(86.0%)cured,4(9.3%) markedly improved,2(4.7%)failed.Total effective rate was 95.3% and so was the elimination rate of my-coplasma.Conclusion The resistant rate of mycoplasma to spectinomycin is lower than that to minocycline、azithromycin and sparfloxacin,and the former is widely used in the treatment of mycoplasma(especially Uu)infection,with a satisfactory clinical effect.

Key words: Spectinomycin, Mycoplasma hominis, Ureaplasma urealyticum, Microbial sensitivity tests