Abstract: Objective To study the correlation between vitamin D receptor(VDR)polymorphism and psoriasis in the Chinese patients.Methods VDR genotypes were determined by PCR-RFLP in 112 unrelated psoriatic patients as well as 108 unrelated healthy controls.Results AA and Bb genotypes were found to be expressed more frequently in psoriatic patients(19.6% and 32.1%)than those in normal controls(7.4% and 14.8%),respectively.However,no signifi cant correlation was identified between VDR polymorphismand sex,age at onset,family history of psoriasis in psoriatic patients.In addition,there was no significant difference in the frequency of A,a alleles and B,b alleles between normal controls and psoriatic patients.Conclusions There is a significant difference in VDR genotypes between psoriatic patients and normal controls.The presence of hom ozygote AA or heterozygote Bb might contribute to the susceptibility of psoriasis.

Key words: Psoriasis, Receptors,calcipotriol, Polymorphism(Genetics)