Abstract: Objective To study the level of expression of RARγ/RXRαmRNA in skin lesions of patients with psoriasis vulgaris.Methods The skin biopsies were collected from skin lesions in 20 cases of psoriasis vulgaris and 10 normal controls.Expression of RARγ/RXRαmRNA was detected by RT-PCR.Results Expression levels of RXRαmRNA were 0.19760±0.0933in epidermides from psoriatic lesions,which were markedly lower than those in normal controls(0.5867±0.0132)(P<0.01).Expression levels of RARγmRNA were 0.5037±0.0883 and 0.5624±0.0767,respectvely,without significant difference(P>0.05).Conclusion The results indicate that decreased expression of RXRαmRNA might be related to the pathogenesis of psoriasis.

Key words: Receptors,retinoic acid, Psoriasis