Abstract: Objective To investigate the effect of potassium iodide on the incidence of sporotrichosis, and provide the theoretical basis for the prevention of sporotrichosis. Methods Experimental mice were divided into 4 groups, group 1～3 were fed with water containing different doses of potassium iodide, and no potassium iodide was given to the control group. After two weeks, the fungi were inoculated intraperitoneally to all the mice. In the third to the eighth weeks, the mice were sacrificed every week in batches. The infection, pathological changes and mycological findings of the mice were observed. Results The incidence rate of experimental sporotrichosis was significantly decreased in the mice (P<0.01), and the decrease was related to the dosage of potassimu iodide. Conclusion The results show that potassium iodide may be of use in the prevention of sporotrichosis.

Key words: Sporotrichosis, Potassium Iodide, Prevention, Experimental animal